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SHR Neuro Cancer Cardio Lipid Metab Microb

Dahaba, AA; Perelman, SI; Moskowitz, DM; Bennett, HL; Shander, A; Xiao, Z; Huang, L; An, G; Bornemann, H; Wilfinger, G; Hager, B; Rehak, PH; List, WF; Metzler, H.
Geographic regional differences in rocuronium bromide dose-response relation and time course of action: an overlooked factor in determining recommended dosage.
ANESTHESIOLOGY. 2006; 104(5): 950-953. Doi: 10.1097/00000542-200605000-00010 [OPEN ACCESS]
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Co-authors Med Uni Graz: Bornemann-Cimenti Helmar; Metzler Helfried; Rehak Peter
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Abstract:: BACKGROUND: Geographic location is not acknowledged as a stratifying factor that can directly affect drug potency, because drugs are still licensed with the same recommended dose for different geographic regions. The aim of the current study was to compare the potency and duration of action of rocuronium bromide in 54 patients in three countries with different life habits, diet, and ambient conditions, namely white Austrians, white North Americans, and Han Chinese in China. METHODS: Neuromuscular block of six consecutive 50-microg/kg rocuronium incremental doses followed by 300 microg/kg was evaluated using the Relaxometer mechanomyograph (Groningen University, Groningen, Holland). Dose-response curves were created using log-dose-probit transformation. The authors compared rocuronium bromide ED50, ED90, and ED95 (effective doses required for 50%, 90%, and 95% first twitch depression, respectively) as well as Dur25 and Dur0.8 (times from last incremental dose administration until 25% first twitch and 0.8 train-of-four ratio recovery, respectively) in patients of the three countries. RESULTS: Rocuronium ED50, ED90, and ED95 were significantly higher in Austrian patients (258 +/- 68, 530 +/- 159, and 598 +/- 189 microg/kg) and Chinese patients (201 +/- 59, 413 +/- 107, and 475 +/- 155 microg/kg) compared with American patients (148 +/- 48, 316 +/- 116, and 362 +/- 149 microg/kg, respectively). Dur25 and Dur0.8 were significantly shorter in Austrian patients (22.3 +/- 5.5 and 36.9 +/- 12.8 min) and Chinese patients (30.4 +/- 7.5 and 45.7 +/- 15.9 min) compared with American patients (36.7 +/- 8.5 and 56.2 +/- 16.7 min, respectively). CONCLUSIONS: The authors demonstrated a significant difference in rocuronium potency and duration of action among patients in the three countries. Larger studies are required for determining dosage recommendations for different geographic regions.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Androstanols - administration and dosage; Anesthesia, General - administration and dosage; Asian Continental Ancestry Group - administration and dosage; Austria - administration and dosage; China - administration and dosage; Diet - administration and dosage; Dose-Response Relationship, Drug - administration and dosage; European Continental Ancestry Group - administration and dosage; Female - administration and dosage; Geography - administration and dosage; Humans - administration and dosage; Life Style - administration and dosage; Male - administration and dosage; Middle Aged - administration and dosage; Neuromuscular Blockade - administration and dosage; Neuromuscular Nondepolarizing Agents - administration and dosage; North America - administration and dosage; Prospective Studies - administration and dosage