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Massone, C; Lozzi, GP; Egberts, F; Fink-Puches, R; Cota, C; Kerl, H; Cerroni, L.
The protean spectrum of non-Hodgkin lymphomas with prominent involvement of subcutaneous fat.
J Cutan Pathol. 2006; 33(6):418-425 Doi: 10.1111/j.0303-6987.2006.00493.x
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Leading authors Med Uni Graz: Cerroni Lorenzo; Massone Cesare
Co-authors Med Uni Graz: Fink-Puches Regina; Kerl Helmut
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Abstract:: Background: Subcutaneous T-cell lymphoma (STCL) represents a controversial entity and a confused concept in the field of cutaneous T-cell lymphomas (CTCLs). Recently, alpha/beta(+)/CD8(+) STCL has been recognized by the new World Health Organization (WHO)-European Organization for Research and Treatment of Cancer (EORTC) classification of primary cutaneous lymphomas as a distinct entity in the group of CTCLs. Observations: We reviewed a series of 53 biopsies from 26 patients (F : M = 19:7; median age: 48; range 18-87) of cutaneous B- and T-cell lymphomas characterized by prominent involvement of the subcutaneous tissue. We could classify our cases according to the following seven categories - (i) STCL: n = 16; (ii) extranodal NK/T-cell lymphoma, nasal type: n = 2; (iii) cutaneous gamma/delta T-cell lymphoma: n = 2; (iv) anaplastic CD30(+) large T-cell lymphoma: n = 1; (v) diffuse large B-cell lymphoma, secondary cutaneous: n = 3; (vi) lymphoplasmacytic lymphoma, secondary cutaneous: n = 1; (vii) specific cutaneous manifestations of myelogenous leukemia: n = 1. Conclusions: We demonstrated the protean nature of lymphomas with prominent involvement of the subcutaneous fat tissues. The term STCL should be restricted to a homogeneous group of cases characterized morphologically by an exclusive involvement of subcutaneous tissues, immunohistochemically by a T-cytotoxic alpha/beta phenotype, and biologically by a relatively good prognosis.
Find related publications in this database (using NLM MeSH Indexing): Adipose Tissue - metabolism Adipose Tissue - pathology; Adolescent -; Adult -; Aged -; Aged, 80 and over -; Biopsy -; Female -; Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor -; Humans -; Immunoenzyme Techniques -; Immunophenotyping -; Lymphoma, T-Cell, Cutaneous - genetics Lymphoma, T-Cell, Cutaneous - metabolism Lymphoma, T-Cell, Cutaneous - pathology; Male -; Middle Aged -; Polymerase Chain Reaction - methods; Skin Neoplasms - genetics Skin Neoplasms - metabolism Skin Neoplasms - pathology; Subcutaneous Tissue - metabolism Subcutaneous Tissue - pathology; Tumor Markers, Biological - metabolism