Medizinische Universität Graz - Research portal
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SHR Neuro Cancer Cardio Lipid Metab Microb
Cupurdija, K; Azzola, D; Hainz, U; Gratchev, A; Heitger, A; Takikawa, O; Goerdt, S; Wintersteiger, R; Dohr, G; Sedlmayr, P.
Macrophages of human first trimester decidua express markers associated to alternative activation.
AMER J REPROD IMMUNOL. 2004; 51(2): 117-122.
Doi: 10.1046/j.8755-8920.2003.00128.x
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- Leading authors Med Uni Graz
- Sedlmayr Peter
- Co-authors Med Uni Graz
- Dohr Gottfried
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- Abstract:
- PROBLEM: Depending on the type of their activation, macrophages may promote TH1- or TH2-type of immune responses. To date, not much is known about the activation phenotype of decidua macrophages, which - together with NK cells - constitute the majority of bone marrow derived cells at this location. METHOD OF STUDY: The study was based on analysis of healthy first trimester decidua by immunohistochemistry and flow cytometry. We analyzed expression of markers characteristic for alternatively activated macrophages (Mphi2). RESULTS: The markers MS-1 (stabilin-1) and coagulation factor XIIIa were found expressed in the interior of decidua macrophages (DMphi). In contrast, indoleamine 2,3-dioxygenase (IDO), an enzyme induced in macrophages by IFNgamma, was not present in DMphi. CONCLUSIONS: First trimester DMphi display phenotypic markers associated to alternatively activated macrophages. In addition, absence of IDO indicates that DMphi are not under a predominant influence of IFNgamma.
- Find related publications in this database (using NLM MeSH Indexing)
- Biological Markers -
- Cell Adhesion Molecules, Neuronal - biosynthesis
- Cell Culture Techniques - biosynthesis
- Decidua - immunology
- Dioxygenases - immunology
- Factor VIIIa - biosynthesis
- Female - biosynthesis
- Flow Cytometry - biosynthesis
- Humans - biosynthesis
- Immunohistochemistry - biosynthesis
- Immunophenotyping - biosynthesis
- Indoleamine-Pyrrole 2,3,-Dioxygenase - biosynthesis
- Interferon Type II - pharmacology
- Macrophage Activation - drug effects
- Macrophage Colony-Stimulating Factor - pharmacology
- Macrophages - immunology
- Oxygenases - biosynthesis
- Pregnancy - biosynthesis
- Pregnancy Trimester, First - immunology
- Receptors, Lymphocyte Homing - immunology
- Find related publications in this database (Keywords)
- factor XIIIa
- flow cytometry
- laser scanning microscopy
- M phi 2
- placenta