Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Scharnagl, H; Petersen, G; Nauck, M; Teichmann, AT; Wieland, H; März, W.
Double-blind, randomized study comparing the effects of two monophasic oral contraceptives containing ethinylestradiol (20 microg or 30 microg) and levonorgestrel (100 microg or 150 microg) on lipoprotein metabolism.
Contraception. 2004; 69(2):105-113
Doi: 10.1016/j.contraception.2003.10.004
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- Leading authors Med Uni Graz
- Scharnagl Hubert
- Co-authors Med Uni Graz
- März Winfried
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- Abstract:
- The effects of two monophasic oral contraceptives containing ethinylestradiol 20 microg in combination with levonorgestrel 100 microg (EE20/LNG100) or 30 microg and 150 microg (EE30/LNG150), respectively, on lipoprotein metabolism was investigated in a double-blind, randomized study of 12 treatment cycles in healthy female volunteers. Total triglycerides (+32% to +46%, p < 0.05 in comparison to baseline) increased significantly. Triglycerides were highest after six cycles of treatment, decreasing thereafter. Total cholesterol (+1% to +7%), apolipoprotein (apo) B (+21% to +29%) and low-density lipoprotein (LDL) cholesterol (+7% to +17%) increased slightly. High-density lipoprotein (HDL) cholesterol decreased slightly (-11% and -5%), HDL triglycerides increased (+16% and +26%). Apo AI did not change during the study, suggesting that the molar concentration of HDL particles did not change. Apo E (-23% to -14%) decreased, and there was a transitory decrease of lipoprotein (a). Essentially, there was no difference regarding the changes in lipoprotein metabolism between the two treatment groups. The effects of the two combinations of ethinylestradiol and levonorgestrel on triglyceride-rich lipoproteins appear less pronounced than those produced by preparations containing third-generation progestins. It is not likely that the changes in lipoprotein metabolism brought about by the two preparations will alter the risk of future cardiovascular disease in a clinically relevant fashion.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Cholesterol - metabolism
- Contraceptive Agents, Female - adverse effects
- Dose-Response Relationship, Drug - adverse effects
- Double-Blind Method - adverse effects
- Estrogens - adverse effects
- Ethinyl Estradiol - adverse effects
- Female - adverse effects
- Humans - adverse effects
- Levonorgestrel - adverse effects
- Lipoproteins - drug effects
- Triglycerides - metabolism
- Find related publications in this database (Keywords)
- apolipoprotein E
- cholesterol
- oral contraceptives
- triglycerides