Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Zebisch, A; Cerroni, L; Beham-Schmid, C; Sill, H.
Therapy-related leukemia cutis: case study of an aggressive disorder.
ANN HEMATOL 2003 82: 705-707.
Doi: 10.1007/s00277-003-0717-y
(- Case Report)
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- Führende Autor*innen der Med Uni Graz
- Sill Heinz
- Zebisch Armin
- Co-Autor*innen der Med Uni Graz
- Beham-Schmid Christine
- Cerroni Lorenzo
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- Abstract:
- Therapy-related leukemia cutis has not yet been described. We report a 55-year-old male who developed aleukemic leukemia cutis 15 months after chemotherapy and radiotherapy for non-Hodgkin's lymphoma. Despite intensive therapy including allogeneic hematopoietic stem cell transplantation, the patient died of progressive disease. Sequence analysis of the TP53 gene and screening for defective DNA mismatch repair revealed no abnormalities. This case demonstrates that therapy-related aleukemic leukemia cutis is an aggressive disorder resistant to conventional antineoplastic treatment approaches. As the number of patients developing therapy-related myelodysplasia or leukemia is increasing, clinicians might be confronted more frequently with atypical, extramedullary presentations of these disorders.
- Find related publications in this database (using NLM MeSH Indexing)
- Base Pair Mismatch - genetics
- DNA Repair - genetics
- Fatal Outcome - genetics
- Genes, p53 - genetics
- Humans - genetics
- Leukemia, Subleukemic - chemically induced
- Leukemic Infiltration - chemically induced
- Lymphoma, Non-Hodgkin - drug therapy
- Male - drug therapy
- Middle Aged - drug therapy
- Mutation - drug therapy
- Peroxidase - metabolism
- Skin - pathology
- Find related publications in this database (Keywords)
- leukemia cutis
- therapy-related neoplasia
- TP53
- microsatellite instability
- allogeneic transplantation