Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Dornbusch, HJ; Strenger, V; Kerbl, R; Lackner, H; Schwinger, W; Sovinz, P; Urban, C.
Procalcitonin and C-reactive protein do not discriminate between febrile reaction to anti-T-lymphocyte antibodies and Gram-negative sepsis.
Bone Marrow Transplant. 2003; 32(9):941-945
Doi: 10.1038/sj.bmt.1704265
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- Führende Autor*innen der Med Uni Graz
- Dornbusch Hans Jürgen
- Co-Autor*innen der Med Uni Graz
- Kerbl Reinhold
- Lackner Herwig
- Ritter-Sovinz Petra
- Schwinger Wolfgang
- Strenger Volker
- Urban Ernst-Christian
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- Abstract:
- Treatment with antibodies against T-lymphocytes usually triggers a febrile response potentially mimicking or masking infection. Procalcitonin (PCT) is considered a sensitive and specific marker of systemic bacterial and fungal infection. It was the aim of this study to investigate the characteristics of PCT and C-reactive protein (CRP) during treatment with polyclonal or monoclonal anti-T-cell antibodies, in order to examine the ability of these parameters to distinguish between systemic bacterial infection and reaction to antibody treatment. Thus, 15 consecutive febrile episodes after T-cell antibody infusion without clinical signs of infection were compared with nine episodes of Gram-negative sepsis. After T-cell antibody infusion PCT and CRP serum levels increased to a similar extent as in Gram-negative sepsis. Therefore, during T-cell antibody treatment neither PCT nor CRP are adequate for differentiating between fever due to infection or to unspecific cytokine release.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Antibodies - adverse effects Antibodies - therapeutic use
- Bacterial Infections - diagnosis
- Biological Markers - blood
- C-Reactive Protein - analysis
- Calcitonin - blood
- Child -
- Child, Preschool -
- Diagnosis, Differential -
- Female -
- Fever - diagnosis Fever - etiology
- Gram-Negative Bacteria -
- Humans -
- Infant -
- Male -
- Neoplasms - complications Neoplasms - therapy
- Protein Precursors - blood
- Sensitivity and Specificity -
- Sepsis - diagnosis
- T-Lymphocytes - immunology
- Find related publications in this database (Keywords)
- antilymphocyte antibodies
- fever
- procalcitonin
- CRP
- sepsis