Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Langner, C; Ratschek, M; Tsybrovskyy, O; Schips, L; Zigeuner, R.
P63 immunoreactivity distinguishes upper urinary tract transitional-cell carcinoma and renal-cell carcinoma even in poorly differentiated tumors.
J Histochem Cytochem. 2003; 51(8):1097-1099
Doi: 10.1177/002215540305100813
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- Führende Autor*innen der Med Uni Graz
- Langner Cord
- Co-Autor*innen der Med Uni Graz
- Ratschek Manfred
- Schips Luigi
- Tsybrovskyy Oleksiy
- Zigeuner Richard
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- Abstract:
- P63 is essential for the differentiation of normal urothelium and is also expressed in transitional cell carcinoma (TCC) of the bladder. We investigated p63 immunoreactivity in upper urinary tract TCC (n=53) and in renal-cell carcinoma (RCC; n=188) using a tissue microarray technique. P63 expression was detected in 51/53 (96.2%) TCCs, showing decreased expression in high-stage (pT1 and pT2 100%; pT3 90.9%) and poorly differentiated (G1 and G2 100%; G3 92%) tumors. All RCCs were negative for p63. P63 proved to be a helpful tool, even in poorly differentiated and undifferentiated renal malignancies, to distinguish TCC from RCC.
- Find related publications in this database (using NLM MeSH Indexing)
- Carcinoma, Renal Cell - diagnosis
- Carcinoma, Transitional Cell - diagnosis
- Humans - diagnosis
- Immunohistochemistry - diagnosis
- Tumor Markers, Biological - metabolism
- Urologic Neoplasms - diagnosis
- Find related publications in this database (Keywords)
- upper urinary tract transitional-cell carcinoma
- renal-cell carcinoma
- immunohistochemistry
- differential diagnosis