Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Liebmann, PM; Reibnegger, G; Lehofer, M; Moser, M; Pürstner, P; Mangge, H; Schauenstein, K.
Circadian rhythm of the soluble p75 tumor necrosis factor (sTNF-R75) receptor in humans--a possible explanation for the circadian kinetics of TNR-alpha effects.
Int Immunol. 1998; 10(9):1393-1396
Doi: 10.1093/intimm/10.9.1393
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- Führende Autor*innen der Med Uni Graz
- Liebmann-Holzmann Peter
- Co-Autor*innen der Med Uni Graz
- Mangge Harald
- Moser Maximilian
- Pürstner Peter
- Reibnegger Gilbert
- Schauenstein Konrad
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- Abstract:
- Circadian alterations of several immune functions in vivo are well established, and may have important physiological and clinical implications. In line with this, tumor necrosis factor (TNF)-alpha has been implicated in the circadian regulation of body temperature. As soluble TNF receptors (TNF-R) act as naturally occurring competitive inhibitors of this cytokine, we investigated plasma levels of the soluble sTNF-R55 and sTNF-R75 in comparison with plasma cortisol and body temperature in nine healthy male volunteers during a defined 16 h light/8 h dark cycle. It was found that sTNF-R75, but not sTNF-R55, exhibited a clear-cut circadian rhythm with a significant (P < 0.01) peak at 7:51 a.m. +/- 58 min. The phase of the sTNF-R75 rhythm preceded that of cortisol by approximately 1 h and inversely corresponded to the circadian rhythm of body temperature. Moreover, the individual amplitudes of sTNF-R75 and body temperature exhibited a significant (P < 0.01) positive correlation. These results suggest that (i) the two sTNF-R are regulated independently, (ii) the sTNF-R75 rhythm is not primarily due to the cortisol rhythm and (iii) the fluctuation of the sTNF-R may contribute to the regulation of body temperature by modulating the availability of free TNF.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Antigens, CD - blood
- Body Temperature - physiology
- Circadian Rhythm -
- Humans -
- Hydrocortisone - blood
- Kinetics -
- Male -
- Receptors, Tumor Necrosis Factor - blood
- Receptors, Tumor Necrosis Factor, Type I -
- Receptors, Tumor Necrosis Factor, Type II -
- Tumor Necrosis Factor-alpha - physiology
- Find related publications in this database (Keywords)
- Body Temperature
- Circadian Rhythm
- Cortisol
- Healthy Male Volunteers