Medizinische Universität Graz - Research portal
Selected Publication:
Sandner-Kiesling, A; Rumpold Seitlinger, G; Dorn, C; Koch, H; Schwarz, G.
Lamotrigine monotherapy for control of neuralgia after nerve section.
Acta Anaesthesiol Scand. 2002; 46(10):1261-1264
Doi: 10.1034%2Fj.1399-6576.2002.461014.x
(- Case Report)
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Sandner-Kiesling Andreas
- Co-authors Med Uni Graz
- Dorn Christian
- Koch Horst
- Rumpold-Seitlinger Gudrun
- Schwarz Gerhard
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- Abstract:
- BACKGROUND: We present six patients treated only with the new-generation anticonvulsant lamotrigine to define its sole effect on neuralgia after nerve section. METHODS: Previous surgical or pharmacological attempts failed to relieve this neuropathic pain in our patients. Before initiation of lamotrigine therapy, patients reported spontaneous and touch-evoked shooting pain followed by periods of burning pain. No breakthrough medication was needed during the maintenance phase of 1-23 months. Data were acquired by a pain diary on a weekly basis. RESULTS: With 75-300 mg of lamotrigine per day, the burning and shooting pain intensity was relieved by 33-100%. Most obviously, the attack frequency of the shooting pain was reduced by 80-100%. No adverse effects were observed. CONCLUSION: We conclude that lamotrigine may be beneficial in the treatment of neuralgia after nerve section following the failure of previous pharmacological or surgical attempts.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Anticonvulsants - therapeutic use
- Autonomic Denervation - adverse effects
- Female - adverse effects
- Humans - adverse effects
- Male - adverse effects
- Middle Aged - adverse effects
- Neuralgia - drug therapy
- Pain Measurement - drug therapy
- Time Factors - drug therapy
- Triazines - therapeutic use
- Find related publications in this database (Keywords)
- anticonvulsant
- mechanical allodynia
- neuropathic pain
- sodium channel blocker
- spontaneous pain