Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Auner, HW; Tinchon, C; Brezinschek, RI; Eibl, M; Sormann, S; Maizen, C; Linkesch, W; Schmon-Kampel, R; Quehenberger, F; Tiran, A; Sill, H.
Monitoring of cardiac function by serum cardiac troponin T levels, ventricular repolarisation indices, and echocardiography after conditioning with fractionated total body irradiation and high-dose cyclophosphamide.
Eur J Haematol. 2002; 69(1):1-6
Doi: 10.1034%2Fj.1600-0609.2002.01661.x
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- Führende Autor*innen der Med Uni Graz
- Sill Heinz
- Co-Autor*innen der Med Uni Graz
- Eibl Margit
- Linkesch Werner
- Quehenberger Franz
- Tiran Andreas
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- Abstract:
- OBJECTIVES: Highly differing rates of cardiac complications associated with high-dose cyclophosphamide (CY) have been reported, and only one clinical study has been performed on the cardiotoxic effects of CY monotherapy following total body irradiation (TBI). PATIENTS AND METHODS: We prospectively evaluated the potential cardiotoxic effects of conditioning with fractionated total body irradiation and high-dose cyclophosphamide (TBI/CY) by serial measurement of serum cardiac troponin T (cTnT), assessment of systolic and diastolic echocardiographic parameters and analysis of ventricular repolarisation indices (QT-dispersion and corrected QT-dispersion) in 30 adult patients with haematological malignancies undergoing haematopoietic stem cell transplantation. RESULTS: There was no evidence of pretreatment cardiac dysfunction in any patient. Although cTnT was determined serially for a median of 14 d after completion of conditioning, no elevated levels were observed. Echocardiographic parameters did not show any significant change at a median follow-up of 5 months except for one patient with evidence of impaired diastolic filling. No significant differences for mean values before and after high-dose CY were noted for ventricular repolarisation indices. Two patients had a significant increase in corrected QT-dispersion after CY without any other signs of cardiotoxicity. Congestive heart failure or arrhythmias were not observed. CONCLUSIONS: These data suggest that TBI/CY is safe with respect to cardiotoxicity in patients without pre-existing cardiac dysfunction. Hitherto unknown synergistic cardiotoxic effects of CY with other cytostatic drugs may constitute the major pathogenic factor of myocardial dysfunction after high-dose chemotherapy.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Cyclophosphamide - administration and dosage
- Echocardiography - administration and dosage
- Heart Function Tests - administration and dosage
- Heart Ventricles - physiopathology
- Hematologic Neoplasms - blood
- Humans - blood
- Immunosuppressive Agents - administration and dosage
- Middle Aged - administration and dosage
- Monitoring, Physiologic - administration and dosage
- Stem Cell Transplantation - administration and dosage
- Transplantation Conditioning - standards
- Troponin T - blood
- Whole-Body Irradiation - standards
- Find related publications in this database (Keywords)
- troponin T
- cyclophosphamide
- total body irradiation
- cardiotoxicity
- transplantation