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Selected Publication:
Korgun, ET; Demir, R; Sedlmayr, P; Desoye, G; Arikan, GM; Puerstner, P; Haeusler, M; Dohr, G; Skofitsch, G; Hahn, T.
Sustained hypoglycemia affects glucose transporter expression of human blood leukocytes.
Blood Cells Mol Dis. 2002; 28(2):152-159
Doi: 10.1006/bcmd.2002.0504
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Hahn Tom
- Co-authors Med Uni Graz
- Desoye Gernot
- Dohr Gottfried
- Haeusler Martin
- Pürstner Peter
- Sedlmayr Peter
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- Abstract:
- The scarce data available on leukocyte glucose transporter expression are contradictory and nothing is known about its regulation by glycemic state. Therefore, cytospin preparations of blood leukocytes were searched immunocytochemically for the high-affinity glucose transporters GLUT1, 3, and 4. Hypoglycemia-associated quantitative changes in transporter expression were assessed by flow cytometry. Granulocytes and monocytes stained for GLUT1, 3, and 4. Granulocyte GLUT4 levels were increased by 73% (P < 0.05) under hypoglycemic conditions, which was paralleled by a reduction in GLUT1 and a rise in GLUT3. In monocytes, GLUT3 was elevated by 134% (P < 0.05), whereas GLUT1 and GLUT4 remained unaffected upon hypoglycemia. Apart from a minor subpopulation, lymphocytes were negative for these carriers. In conclusion, GLUT1, 3, and 4 are abundantly expressed in granulocytes and monocytes. The differential response of individual isoforms to hypoglycemia may represent a mechanism to protect the cells from the stress of glucose deprivation.
- Find related publications in this database (using NLM MeSH Indexing)
- Adaptation, Biological -
- Female -
- Glucose Transporter Type 1 -
- Glucose Transporter Type 3 -
- Glucose Transporter Type 4 -
- Granulocytes - chemistry Granulocytes - metabolism
- Humans -
- Hypoglycemia - blood Hypoglycemia - metabolism
- Leukocytes - chemistry Leukocytes - metabolism
- Monocytes - chemistry Monocytes - metabolism
- Monosaccharide Transport Proteins - metabolism
- Muscle Proteins -
- Nerve Tissue Proteins -
- Find related publications in this database (Keywords)
- GLUT granulocyte
- leukocytosis
- lymphocyte
- monocyte
- starvation