Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Pfragner, R; Wirnsberger, GH; Ingolic, E; Niederle, B.
Medullary thyroid carcinomas in cell culture--models for future therapies.
Wien Klin Wochenschr. 2002; 114(7):279-283
Web of Science
PubMed
- Führende Autor*innen der Med Uni Graz
- Pfragner Roswitha
- Co-Autor*innen der Med Uni Graz
- Wirnsberger Gerhard
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- Abstract:
- We report the successful establishment of seven human medullary thyroid carcinomas (MTC) as continuous cell lines. Characteristic features--such as the presence of neuroendocrine granules--and the positive immunoreactivity to antibodies to CT, CGRP, GRP, SRIF, 5-HT, NSE, PHE, LK2H10, ER and Pgr were followed throughout the cultivation. An overexpression of the antiapoptotic gene bcl-2 was detected in the cell lines. Deregulation of apoptosis plays an important role in multistep tumorigenesis. MTCs are known for the phenomenon of bcl-2-based chemo- and radioresistance. Our studies focus on influencing the growth rates and modulating the apoptotic rates by treatment with proliferation-modifying substances and anticancer drugs. Our MTC cell lines are useful models for these in vitro studies.
- Find related publications in this database (using NLM MeSH Indexing)
- Carcinoma, Medullary - drug therapy
- Cell Survival - drug effects
- Gene Expression Regulation, Neoplastic - genetics
- Humans - genetics
- Microscopy, Electron - genetics
- Microscopy, Electron, Scanning - genetics
- Proto-Oncogene Proteins c-bcl-2 - genetics
- Thyroid Neoplasms - drug therapy
- Tumor Cells, Cultured - drug effects
- Tumor Stem Cell Assay - drug effects
- Find related publications in this database (Keywords)
- medullary thyroid carcinoma
- new cell lines
- multidrug resistance
- apoptosis