Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Seinost, G; Gasser, R; Reisinger, E; Rigler, MY; Fischer, L; Keplinger, A; Dattwyler, RJ; Dunn, JJ; Klein, W.
Cardiac manifestations of Lyme borreliosis with special reference to contractile dysfunction
Acta Med Austriaca. 1998; 25(2):44-50
Web of Science
PubMed
- Führende Autor*innen der Med Uni Graz
- Seinost Gerald
- Co-Autor*innen der Med Uni Graz
- Gasser Robert
- Rigler Marcus Yves
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- Abstract:
- Borrelia burgdorferi infection (BBI) is suggested to be associated with dilated cardiomyopathy (IDC). Stanek et al. were able to cultivate Borrelia burgdorferi (BB) from myocardial biopsy tissue of a patient with longstanding dilated cardiomyopathy. Here we present a study in which we examined the effect of standard antibiotic treatment on the left ventricular ejection fraction (LV-EF) in patients with dilated cardiomyopathy associated with BBI. In this study we assessed the serum (IgG, IgM ELISA; Western Blot) and the history of 46 IDC-patients with specific respect spect to BBI (mean LV-EF: 30.4 +/- 1.3%; measured by cardiac catheterisation and echocardiography--length-area-volume method). All 46 patients received standard treatment for dilated cardiomyopathy: ACE-inhibitors, digitalis and diuretics. 11 (24%) patients showed positive serology and a history of BBI; 9 of these also had a typical history of tick bite and erythema chronicum migrans (ECM) and/or other organ involvement, 2 had no recollection of tick bite or EMC, but showed other BB-associated disorders (neuropathy, oligoarthritis). These 11 patients with BBI received standard antibiotic treatment with intravenous ceftriaxone 2 g bid for 14 days. 6 (55%) recovered completely and showed a normal LV-EF after 6 months, 3 (27%) improved their LV-EF and 2 (18%) did not improve at all. This amounts to 9 (82%) recovery/improvement in the BB-group. The 35 patients who did not show positive serology or a history of BBI did not receive antibiotic treatment. In this group without BBI 12 (26%) showed recovery/improvement following the standard treatment of dilated cardiomyopathy (see above). Our results indicate that BBI could play a decisive role in the development of dilated cardiomyopathy, especially in a geographical region as Graz, where BB is endemic. While aware of the small number of BB-patients in this study, we nevertheless conclude that, in a remarkable number of patients with signs of BBI, dilated cardiomyopathy could be reversed and LV-EF improved upon standard antibiotic treatment.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Cardiomyopathy, Dilated - diagnosis
- Cardiovascular Agents - therapeutic use
- Ceftriaxone - administration and dosage
- Drug Therapy, Combination - administration and dosage
- Echocardiography - administration and dosage
- Female - administration and dosage
- Heart Catheterization - administration and dosage
- Humans - administration and dosage
- Infusions, Intravenous - administration and dosage
- Lyme Disease - diagnosis
- Male - diagnosis
- Middle Aged - diagnosis
- Myocardial Contraction - drug effects
- Stroke Volume - drug effects
- Treatment Outcome - drug effects
- Ventricular Function, Left - drug effects
- Find related publications in this database (Keywords)
- Dilated Cardiomyopathy
- Lyme Disease
- Antibiotics
- Ceftriaxone
- Borrelia Burgdorferi