Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

Fink-Puches, R; Pilarski, P; Schmidbauer, U; Kerl, H; Soyer, HP.
No evidence for c-erbB-2 overexpression in cutaneous melanoma.
Anticancer Res. 2001; 21(4A):2793-2795
Web of Science PubMed Google Scholar

Leading authors Med Uni Graz: Fink-Puches Regina; Soyer Hans Peter
Co-authors Med Uni Graz: Kerl Helmut
Altmetrics:
Dimensions Citations:
Plum Analytics:
Abstract:: BACKGROUND: Recent studies have demonstrated the expression of the c-erbB-2 (HER-2/neu) oncoprotein in several malignant tumors and have related its overexpression with poor prognosis. Because cutaneous melanoma is a malignant tumor associated with poor prognosis, we investigated the expression of c-erbB-2 protein in cutaneous melanoma and in melanoma metastatic to the skin. MATERIALS AND METHODS: The expression of c-erbB-2 protein in 20 primary cutaneous melanomas and in 10 melanomas metastatic to the skin was investigated using a semi-quantitative immunohistochemical assay. RESULTS: No specific staining with c-erbB-2 antibody was observed in any of the 20 cases of primary malignant melanoma or 10 cases of melanoma metastatic to the skin. CONCLUSION: c-erbB-2 overexpression does not appear to play a role in the development of primary cutaneous melanoma or in the development of metastatic melanoma, indicating that mechanisms other than c-erbB-2 overexpression are involved in the pathogenesis of cutaneous melanoma.
Find related publications in this database (using NLM MeSH Indexing): Humans -; Immunohistochemistry -; Melanoma - genetics; Receptor, erbB-2 - biosynthesis; Skin Neoplasms - genetics
Find related publications in this database (Keywords): cutaneous melanoma; c-erbB-2-overexpression; immunohistochemistry; prognosis