Medizinische Universität Graz - Research portal
Selected Publication:
Korgun, ET; Demir, R; Hammer, A; Dohr, G; Desoye, G; Skofitsch, G; Hahn, T.
Glucose transporter expression in rat embryo and uterus during decidualization, implantation, and early postimplantation.
BIOL REPROD 2001 65: 1364-1370.
Doi: 10.1095/biolreprod65.5.1364
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Leading authors Med Uni Graz
- Hahn Tom
- Co-authors Med Uni Graz
- Desoye Gernot
- Dohr Gottfried
- Hammer Astrid
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Efficient transfer of glucose from the mother to the embryonic compartment is crucial to sustain the survival and normal development of the embryo in utero, because the embryo's production of this primary substrate for oxidative metabolism is minimal. In the present study, the temporal sequence of expression of the sodium-independent facilitative glucose transporter isoforms GLUTs 1, 3, 4, and 5 was investigated in the developing rat uteroembryonic unit between conception and Gestational Day 8 using immunohistochemistry. The GLUTs 1, 3, and 4 were expressed in the embryonic tissues after the start of implantation, being colocalized in the parietal endoderm, visceral endoderm, primary ectoderm, extraembryonic ectoderm, and the ectoplacental cone. In the uterus, a faint GLUT1 labeling emerged, but not until Gestational Day 3, in the luminal epithelium, endometrial stroma, and decidual cells. The intensity of GLUT1 staining increased in the latter population with progressing decidualization. Endometrial glands and myometrial smooth muscle cells stained neither for GLUT1 nor for GLUT3 until postimplantation. During all developmental stages examined, GLUT4 was visualized throughout the pregnant rat uterus, as was GLUT3 (with the above-mentioned exceptions). The density of GLUT5 was generally less than the sensitivity of the immunohistochemical detection method in all tissues investigated. In conclusion, the data point to a significant expression of the high-affinity glucose transporters GLUTs 1, 3, and 4 in the rat uteroembryonic unit, providing supportive evidence for an important role of facilitative glucose diffusion during peri-implantation development.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Decidua - physiology
- Embryo - chemistry
- Embryo Implantation - chemistry
- Embryonic Development - chemistry
- Female - chemistry
- Gestational Age - chemistry
- Glucose Transporter Type 1 - chemistry
- Glucose Transporter Type 3 - chemistry
- Glucose Transporter Type 4 - chemistry
- Immunohistochemistry - chemistry
- Monosaccharide Transport Proteins - analysis
- Muscle Proteins - analysis
- Nerve Tissue Proteins - analysis
- Pregnancy - analysis
- Rats - analysis
- Rats, Wistar - analysis
- Tissue Distribution - analysis
- Uterus - chemistry
- Find related publications in this database (Keywords)
- decidua
- early development
- implantation
- placental transport
- uterus