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Selected Publication:
Zöhrer', B; Zenz, W; Rettenbacher, A; Covi, P; Kurnik, K; Kroll, H; Grubbauer, HM; Muntean, W.
Danaparoid sodium (Orgaran) in four children with heparin-induced thrombocytopenia type II.
ACTA PAEDIAT. 2001; 90(7): 765-771.
Doi: 10.1080/080352501750315672
(- Case Report)
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Zenz Werner
- Zöhrer Bettina
- Co-authors Med Uni Graz
- Grubbauer Hans
- Muntean Eugen
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- Abstract:
- We report on four children with heparin-induced thrombocytopenia type II. In three patients, therapy with unfractionated heparin was associated with development of cardiac thrombi or with thrombosis progression up to the inferior vena cava or with aggravation of peripheral arterial occlusion. In the fourth child, the disease was recognized early on, and no complication occurred. Heparin-induced thrombocytopenia type II was confirmed by heparin-induced platelet activation assay and/or heparin/platelet factor 4-ELISA. Concomitant elevated antiphospholipid antibodies were seen in all patients. Danaparoid sodium applied at a dosage of between 1.2 and 7.1 U/kg/h stopped the disease progression in each patient. Three children had a clinical recovery with partial recanalization, but for the child with peripheral arterial occlusion disease, amputation of some of the toes became necessary. CONCLUSION: Our data indicate that heparin-induced thrombocytopenia type II is a potential life-threatening disease in children and danaparoid sodium is beneficial in this age group.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Antibodies, Antiphospholipid - blood
- Anticoagulants - administration and dosage
- Child - administration and dosage
- Chondroitin Sulfates - administration and dosage
- Dermatan Sulfate - administration and dosage
- Female - administration and dosage
- Heparin - adverse effects
- Heparitin Sulfate - administration and dosage
- Humans - administration and dosage
- Male - administration and dosage
- Thrombocytopenia - chemically induced
- Thrombosis - drug therapy
- Treatment Outcome - drug therapy
- Find related publications in this database (Keywords)
- antiphospholipid antibodies
- children
- danaparoid sodium
- heparin-induced thrombocytopenia
- thrombosis