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SHR Neuro Cancer Cardio Lipid Metab Microb
Kovacevic, A; Hammer, A; Sundl, M; Pfister, B; Hrzenjak, A; Ray, A; Ray, BK; Sattler, W; Malle, E.
Expression of serum amyloid A transcripts in human trophoblast and fetal-derived trophoblast-like choriocarcinoma cells.
FEBS LETT. 2006; 580(1): 161-167.
Doi: 10.1016/j.febslet.2005.11.067
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- Leading authors Med Uni Graz
- Malle Ernst
- Co-authors Med Uni Graz
- Hammer Astrid
- Hrzenjak Andelko
- Sattler Wolfgang
- Sundl Monika
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- Abstract:
- The placenta comprises a highly specialized trophoblast layer, which arises from the embryo and differentiates during embryonic development to perform specialized functions, e.g., synthesis of pregnancy-associated hormones, growth factors and cytokines. As there is no evidence of maternal acute-phase protein transplacental transfer and trophoblast plays an important role in regulating immune responses at the feto-maternal interface, the expression of acute-phase serum amyloid A (A-SAA) was investigated in human first trimester trophoblast and trophoblast-like JAR and Jeg-3 choriocarcinoma cells. We here show expression of cytokine receptors and cytokine-dependent induction of A-SAA in JAR and Jeg-3 cells. While interleukin-1alpha/beta is a major agonist for A-SAA expression in JAR, tumor necrosis factor-alpha is the predominant agonist in Jeg-3. First trimester trophoblast and JAR/Jeg-3 cells further express the human homolog of SAA-activating factor-1, a transcription factor involved in cytokine-mediated induction of A-SAA genes. A-SAA1 and A-SAA2 transcripts were increased in first trimester trophoblast during pregnancy weeks 10 and 12 suggesting that A-SAA plays a role during early fetal development.
- Find related publications in this database (using NLM MeSH Indexing)
- Cell Line, Tumor -
- Choriocarcinoma - immunology
- Female - immunology
- Fetal Development - immunology
- Gene Expression Regulation - drug effects
- Humans - drug effects
- Maternal-Fetal Exchange - immunology
- Pregnancy - immunology
- Serum Amyloid A Protein - biosynthesis
- Trophoblasts - cytology
- Tumor Necrosis Factor-alpha - immunology
- Find related publications in this database (Keywords)
- acute-phase SAA
- apolipoprotein
- cytokine
- inflammation
- fetal development