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Selected Publication:
Brunner, GA; Balent, B; Ellmerer, M; Schaupp, L; Siebenhofer, A; Jendle, JH; Okikawa, J; Pieber, TR.
Dose-response relation of liquid aerosol inhaled insulin in type I diabetic patients.
Diabetologia. 2001; 44(3):305-308
Doi: 10.1007%2Fs001250051618
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- Leading authors Med Uni Graz
- Brunner Gernot
- Co-authors Med Uni Graz
- Ellmerer Martin
- Pieber Thomas
- Schaupp Lukas
- Siebenhofer-Kroitzsch Andrea
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- Abstract:
- AIMS/HYPOTHESIS: The AERx insulin Diabetes Management system (AERx iDMS) is a liquid aerosol device that enables insulin to be administered to the peripheral parts of the lung. This study aimed to compare the pharmacokinetic and pharmacodynamic properties of insulin which is inhaled using AERx iDMS with insulin which is subcutaneously administered. METHODS: In total, 18 C-peptide negative patients with Type I (insulin-dependent) diabetes mellitus participated in this randomised, open-label, 5-period crossover trial. Human regular insulin was administered subcutaneously (0.12 U/kg body weight) or inhaled by means of the AERx iDMS (dosages 0.3, 0.6, 1.2, and 1.8 U/kg body weight). Thereafter plasma glucose was kept constant at 7.2 mmol/l for a 10-h period (glucose clamp technique). RESULTS: Inhaled insulin provided a dose-response relation that was close to linear for both pharmacokinetic (AUC-Ins(0-10 h); Cmax-Ins) and pharmacodynamic (AUC-GIR(0-10 h); GIRmax) parameters. Time to maximum insulin concentration (Tmax-Ins) and time to maximum glucose infusion rate (TGIRmax) were shorter with inhaled insulin than with subcutaneous administration. The pharmacodynamic system efficiency of inhaled insulin (AUC-GIR(0-6 h) was 12.7% (95% C.I.: 10.2-15.6). CONCLUSION/INTERPRETATION: The inhalation of soluble human insulin using the AERx iDMS is feasible and provides a clear dose response. Further long-term studies are required to investigate safety aspects, HbA1c values, incidence of hypoglycaemic events and the quality of life.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Inhalation -
- Adult -
- Aerosols -
- Area Under Curve -
- Blood Glucose - drug effects
- C-Peptide - blood
- Diabetes Mellitus, Type 1 - blood
- Dose-Response Relationship, Drug - blood
- Humans - blood
- Hypoglycemic Agents - administration and dosage
- Injections, Subcutaneous - administration and dosage
- Insulin - administration and dosage
- Time Factors - administration and dosage
- Find related publications in this database (Keywords)
- Type I diabetes
- inhaled insulin
- pulmonary insulin
- pharmacokinetics
- pharmacodynamics
- insulin therapy