Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Hilbe, W; Eisterer, W; Schmid, C; Starz, I; Silly, H; Duba, C; Ludescher, C; Thaler, J.
Bone marrow lymphocyte subsets in myelodysplastic syndromes.
J CLIN PATHOL. 1994; 47(6): 505-507.
Doi: 10.1136/jcp.47.6.505
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- Co-Autor*innen der Med Uni Graz
- Sill Heinz
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- Abstract:
- AIM--To examine lymphocyte subsets in patients with myelodysplastic syndromes (MDS); and to correlate immunohistological variables with prognosis. METHODS--Bone marrow trephine biopsy specimens from 65 patients with MDS were immunophenotyped using a panel of antibodies. A minimum of 1000 cells from representative areas of marrow sections were counted at light microscopy. The association between immunohistological variables and prognosis was assessed. RESULTS--Compared with normal control marrows (n = 23) no major abnormalities of T cells (CD3), T cell subsets (CD4, CD8, CD25, TCR gamma/delta) or natural killer cells (CD56, CD57) were seen in the 65 patients. In high risk MDS (RAEB, RAEB-t) 19% of the cases showed increased numbers of B lymphocytes compared with none in the low risk group (RA, RARS) (p < 0.0090). Only percentages of B cells above 3% significantly correlated with poor survival (p = 0.0121 for CD19, p = 0.046 for CD22). CONCLUSIONS--The deviations in T lymphocyte counts seen in peripheral blood and in bone marrow aspirates could not be verified in bone marrow biopsy specimens.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- B-Lymphocyte Subsets - immunology
- B-Lymphocytes - cytology
- Bone Marrow - immunology
- Child - immunology
- Child, Preschool - immunology
- Female - immunology
- Humans - immunology
- Immunophenotyping - immunology
- Leukocyte Count - immunology
- Lymphocyte Subsets - immunology
- Male - immunology
- Middle Aged - immunology
- Myelodysplastic Syndromes - immunology
- Prognosis - immunology
- T-Lymphocyte Subsets - immunology
- T-Lymphocytes - cytology