Medizinische Universität Graz - Research portal
Selected Publication:
Mahla, E; Lang, T; Vicenzi, MN; Werkgartner, G; Maier, R; Probst, C; Metzler, H.
Thromboelastography for monitoring prolonged hypercoagulability after major abdominal surgery.
Anesth Analg. 2001; 92(3):572-577
Doi: 10.1213/00000539-200103000-00004
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Mahla Elisabeth
- Co-authors Med Uni Graz
- Maier Robert
- Metzler Helfried
- Vicenzi Martin
- Werkgartner Georg
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Despite clinical and laboratory evidence of perioperative hypercoagulability, there are no consistent data evaluating the extent, duration, and specific contribution of platelets and procoagulatory proteins by in vitro testing. We tested the hypothesis that the parallel use of standard and abciximab-cytochalasin D-modified thromboelastography (TEG(R)) can assess 7 days' post-operative hypercoagulability and can estimate the independent contribution of procoagulatory proteins and platelets. Thromboelastograms were performed before surgery, at the end of surgery, 6 h after surgery, and on postoperative days 1, 2, 3, and 7; they were analyzed for the reaction time and the maximal amplitude (MA). We calculated the elastic shear modulus of standard MA (G(t)) and modified MA (G(c)), which reflect total clot strength and procoagulatory protein component, respectively. The difference was an estimate of the platelet component (G(p)). There was a 10% perioperative increase of standard MA, corresponding to a 50% increase of G(t) (P < 0.0001) and an 86%-90% contribution of the calculated G(p) to G(t). We conclude that serial standard and modified thromboelastography may reveal prolonged postoperative hypercoagulability and the independent contribution of platelets and procoagulatory proteins to clot strength.
- Find related publications in this database (using NLM MeSH Indexing)
- Abdomen - surgery
- Adult -
- Aged -
- Blood Coagulation -
- Blood Platelets - physiology
- Female -
- Humans -
- Male -
- Middle Aged -
- Thrombelastography -
- Time Factors -