Medizinische Universität Graz - Research portal
Selected Publication:
Kostner, K; Spitzauer, S; Rumpold, H; Maurer, G; Knipping, G; Hrzenjak, A; Frank, S; Kostner, GM.
Urinary excretion of apolipoprotein(a): relation to other plasma proteins.
Clin Chim Acta. 2001; 304(1-2):29-37
Doi: 10.1016%2FS0009-8981%2800%2900394-6
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Kostner Gerhard
- Co-authors Med Uni Graz
- Frank Sasa
- Hrzenjak Andelko
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- The atherogenic lipoprotein Lp(a) consists of an LDL-like core and apo(a), linked to apoB via a thiol bridge. Apo(a) fragments ranging in size from 60 to 220 kDa are excreted into urine and the excretion rate correlates significantly with the plasma levels of Lp(a). In order to study the interrelationship of apo(a) secretion with that of other plasma proteins, urinary apo(a) and protein secretion of five probands were followed for 24 h at different urinary densities. The excretion rate of apo(a) fragments, despite their high molecular weight, was highest, followed by apoD, orosomucoid, albumin and beta(2)-glycoprotein-I (beta2-GI) and plasminogen (1.58, 0.87, 0.095, 0.027, 0.013 and <0.001%/day, respectively). There was a highly significant correlation between apo(a), apoD and beta2-GI concentrations but not with albumin and orosomucoid concentrations in urine. The only protein that was fragmented in urine was apo(a) while the other proteins had molecular weights comparable to those in plasma. We conclude that a previously suggested fragmentation of apo(a) by the kidney is not a rate-limiting step in its excretion. Since plasminogen, another kringle-IV-containing plasma compound, and fragments thereof, are undetectable in urine under identical experimental conditions, it is very unlikely that the characteristic kringle structure is responsible for the high excretion rate of apo(a).
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Apolipoproteins - urine
- Apoprotein(a) - urine
- Blood Proteins - urine
- Blotting, Western - urine
- Electrophoresis, Polyacrylamide Gel - urine
- Enzyme-Linked Immunosorbent Assay - urine
- Female - urine
- Humans - urine
- Lipoprotein(a) - urine
- Male - urine
- Middle Aged - urine
- Reference Standards - urine
- Sensitivity and Specificity - urine
- Find related publications in this database (Keywords)
- atherosclerosis
- ApoD
- beta(2)-glycoprotein-I
- orosomucoid
- catabolism