Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Griesbacher, T.
Blood pressure reflexes following activation of capsaicin-sensitive afferent neurones in the biliopancreatic duct of rats.
Br J Pharmacol. 1994; 111(2):547-554
Doi: 10.1111/j.1476-5381.1994.tb14772.x
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- Führende Autor*innen der Med Uni Graz
- Griesbacher Thomas
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- Abstract:
- 1. Inflammatory diseases of the pancreas or diseases which cause obstruction within the biliary or within the biliary or pancreatic duct system are associated with severe pain. Although neuropeptides such as substance P are present in the biliary tree, only few capsaicin-sensitive, substance P-positive nerve fibres have been found in the ducts. In order to obtain functional evidence whether capsaicin-sensitive afferent neurones transmit nociceptive information arising from the biliopancreatic duct, blood pressure reflexes following electrical stimulation of the duct or increases in intraductal pressure were determined in barbiturate-anaesthetized rats. 2. Electrical stimulation of neurones in the biliopancreatic duct was carried out at 30 V, 3 ms, 50 Hz for 20s. In untreated animals the electrical stimulation resulted in rises in blood pressure by up to 25 mmHg, but in about a quarter of all animals tested this response was absent. Following the administration of phentolamine (7 mumol kg-1, i.p.) the blood pressure responses were changed to pronounced and reproducible depressor reflexes of -5 to -30 mmHg. Retrograde injections into the biliopancreatic duct of 300 microliters of a 154 mM sodium chloride solution produced increases in intraductal pressure of approximately 10 mmHg. This elicited shortlasting falls in blood pressure of 3-15 mmHg. Phentolamine significantly augmented the fall in blood pressure to 8-30 mmHg. 3. The depressor reflexes observed in both models after the administration of phentolamine were abolished by morphine (1 mumol kg-1, i.v.). The inhibition by morphine was reversed by naloxone (3 mumol kg-1, i.v.).(ABSTRACT TRUNCATED AT 250 WORDS)
- Find related publications in this database (using NLM MeSH Indexing)
- Adrenalectomy -
- Adrenergic beta-Antagonists - pharmacology
- Animals - pharmacology
- Bile Ducts, Extrahepatic - drug effects
- Blood Pressure - drug effects
- Capsaicin - pharmacology
- Electric Stimulation - pharmacology
- Female - pharmacology
- Morphine - pharmacology
- Naloxone - pharmacology
- Neurons, Afferent - drug effects
- Nociceptors - drug effects
- Pancreatic Ducts - drug effects
- Phentolamine - pharmacology
- Rats - pharmacology
- Rats, Sprague-Dawley - pharmacology
- Reflex - drug effects
- Sympathectomy, Chemical - drug effects
- Find related publications in this database (Keywords)
- Pain (Biliary)
- Pain Reflexes
- Capsaicin
- Afferent Neurons