Medizinische Universität Graz - Research portal
Selected Publication:
Roller, RE; Janisch, S; Kvas, E; Schnedl, WJ; Binder, BR; Wojta, J; Korninger, C.
Smooth muscle cell migration promoting activity of plasma predicts restenosis in patients with peripheral arterial occlusive disease undergoing angioplasty.
Thromb Haemost. 2000; 84(6):1113-1116
Doi: 10.1055/s-0037-1614179
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Roller-Wirnsberger Regina
- Co-authors Med Uni Graz
- Schnedl Wolfgang
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- Abstract:
- Efficacy of percutaneous transluminal angioplasty (PTA) is limited by restenosis occurring in a large proportion of patients. Smooth muscle cell (SMC) migration is a major pathomechanism of restenosis. We studied SMC migration inducing activity of plasma from patients with peripheral arterial occlusive disease (PAOD) undergoing PTA. SMC migration was determined in a two-dimensional assay system after addition of 1/25 plasma dilutions. Mean increase in migration area was 65.5 +/- 33.8% in normal controls and 67.7 +/- 53.2% in patients with PAOD. 6 hours after PTA, plasmatic migration inducing activity was largely unchanged. In 19/30 patients with restenosis (6 months after PTA) migration promoting activity (82.7 +/- 60.0) was significantly higher than in 11/30 patients with patent vessels (41.8 +/- 21.0; p = 0.03). No correlation of clinical risk factors with outcome was observed. A weak correlation was found between plasmatic migration promoting activity and levels of epidermal growth factor and transforming growth factor-beta. The capacity of human plasma to stimulate SMC migration in tissue culture can be used to assess the risk for restenosis after PTA in patients with PAOD.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Analysis of Variance -
- Angioplasty, Balloon - adverse effects
- Arterial Occlusive Diseases - metabolism
- Arterial Occlusive Diseases - pathology
- Case-Control Studies -
- Cell Movement - drug effects
- Culture Techniques -
- Female -
- Graft Occlusion, Vascular - etiology
- Growth Substances - blood
- Growth Substances - pharmacology
- Humans -
- Male -
- Middle Aged -
- Muscle, Smooth, Vascular - pathology
- Peripheral Vascular Diseases - metabolism
- Peripheral Vascular Diseases - pathology
- Peripheral Vascular Diseases - therapy
- Plasma - chemistry
- Treatment Outcome -
- Umbilical Arteries - cytology
- Umbilical Arteries - drug effects
- Find related publications in this database (Keywords)
- peripheral arterial occlusive disease
- angioplasty
- restenosis
- smooth muscle cells
- growth factors