Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Schimpl, G; Pesendorfer, P; Kuesz, AM; Ratschek, M; Höllwarth, ME.
The impact of hepatic xanthine oxidase and xanthine dehydrogenase activities on liver function in chronic cholestasis.
PEDIAT SURG INT 2000 16: 297-301.
Doi: 10.1007%2Fs003830050748
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Führende Autor*innen der Med Uni Graz
- Schimpl Guenther
- Co-Autor*innen der Med Uni Graz
- Höllwarth Michael
- Ratschek Manfred
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Activities of hepatic xanthine oxidase (XO) and xanthine dehydrogenase (XD), serum liver enzymes, and reduced glutathione (GSH) were determined in livers of chronic cholestatic rats. The common bile duct was ligated (CBDL) and rats were randomized to either an untreated group or to treatment with allopurinol, a competitive XO inhibitor, or received a tungsten-supplemented diet to inactivate XO and XD, or received antioxidants vitamin C and vitamin E. One group underwent only sham laparotomy. After 4 weeks, in untreated CBDL animals serum aspartate aminotransferase and bilirubin concentrations were significantly elevated and hepatic GSH was significantly decreased when compared with the sham-operated group. Histochemical and enzymatic determinations of XD and XO showed a significant increase in hepatic XO activity after CBDL. Treatment with allopurinol and a tungsten-supplemented, molybdenum-free diet significantly attenuated serum liver enzymes, hepatic XO activity, and improved hepatic GSH levels, whereas vitamins C and E had a positive effect only on hepatic GSH levels. Our results support the hypothesis that cholestasis-induced hepatocellular injury is partially triggered by oxidative processes derived from increased hepatic XO activity. Inhibition and inactivation of XO exerts a hepatocellular protective effect in chronic cholestasis.
- Find related publications in this database (using NLM MeSH Indexing)
- Allopurinol - pharmacology
- Animals - pharmacology
- Cholestasis - enzymology
- Chronic Disease - enzymology
- Enzyme Inhibitors - pharmacology
- Glutathione - metabolism
- Liver - enzymology
- Male - enzymology
- Random Allocation - enzymology
- Rats - enzymology
- Rats, Sprague-Dawley - enzymology
- Tungsten - enzymology
- Xanthine Dehydrogenase - metabolism
- Xanthine Oxidase - metabolism
- Find related publications in this database (Keywords)
- cholestasis
- xanthine oxidase
- allopurinol
- tungsten diet