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Selected Publication:
Brunner, GA; Hirschberger, S; Sendlhofer, G; Wutte, A; Ellmerer, M; Balent, B; Schaupp, L; Krejs, GJ; Pieber, TR.
Post-prandial administration of the insulin analogue insulin aspart in patients with Type 1 diabetes mellitus.
Diabet Med. 2000; 17(5):371-375
Doi: 10.1046/j.1464-5491.2000.00289.x
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Brunner Gernot
- Co-authors Med Uni Graz
- Balent Beate
- Ellmerer Martin
- Krejs Günter Josef
- Pieber Thomas
- Schaupp Lukas
- Sendlhofer Gerald
- Wutte Andrea-Maria
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- Abstract:
- Aims In intensified insulin therapy, the recent development of short-acting insulin analogues with a very rapid onset of action forces a new discussion in terms of the optimal injection-meal interval. This study evaluated prandial glycaemia in patients with Type 1 diabetes following the subcutaneous injection of soluble human insulin (HI) and the insulin analogue insulin aspart (IAsp) at different injection-meal intervals and investigated whether administration of IAsp after the meal might provide satisfactory metabolic control.Methods In a randomized, double-blind, double-dummy, four-period crossover study, 20 Type 1 diabetic patients were investigated. Prandial insulin was administered 15 min before the start of the meal (HI(-15min)), immediately before the meal (HI(0min); IAsp((0min))) and 15 min after the start of the meal (IAsp((+15min))).Results Plasma glucose excursions from baseline levels during the 4 h (PG(exc)) were highest with HI(0min) (17.9 mmol.l(-1).h; P < 0.05 vs. other treatments) and were not statistically different for HI(-15min), IAsp((0min)) and IAsp((15min)) (13.6, 11.9 and 14.2 mmol.l(-1).h, respectively). Maximum concentration of plasma glucose (PG(max)) was lowest with IAsp((0min)) (11.2 mmol/l; P < 0.05 vs. other treatments). PG(max) was comparable with HI(-15min), HI(0min) and IAsp((+15min)) (13.3, 14.1 and 13.2 mmol/l, respectively).Conclusions With regard to prandial glycaemia IAsp((+15min)) is as effective as HI(- 5min) and superior to HI(0min). Thus, post-prandial dosing of the insulin analogue IAsp offers an attractive and feasible therapeutic option for well-controlled patients with Type 1 diabetes mellitus.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Blood Glucose - metabolism
- Cross-Over Studies -
- Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - drug therapy
- Double-Blind Method -
- Female -
- Food -
- Humans -
- Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - therapeutic use
- Insulin - administration & dosage Insulin - analogs & derivatives Insulin - therapeutic use
- Insulin Aspart -
- Male -
- Middle Aged -
- Find related publications in this database (Keywords)
- injection-meal interval
- insulin analogue
- insulin aspart
- insulin therapy
- soluble human insulin