Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Luxenberger, W; Posch, U; Berghold, A; Hofmann, T; Lang-Loidolt, D.
HLA patterns in patients with nasal polyposis.
Eur Arch Otorhinolaryngol. 2000; 257(3):137-139
Doi: 10.1007/s004050050210
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Luxenberger Wolfgang
- Co-Autor*innen der Med Uni Graz
- Berghold Andrea
- Hofmann Thiemo
- Lang-Loidolt Doris
- Posch Ursula
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- Abstract:
- The etiology of nasal polyposis is still unknown, although risk factors include Aspirin intolerance, asthma, cystic fibrosis and primary ciliary dyskinesia. We studied frequencies of HLA A, B, DR and DQ in patients with nasal polyposis in order to determine a possible genetic component in the multifactorial pathogenesis of nasal polyps. Previous work has suggested an association of HLA-A1B8 with nasal polyposis and Aspirin intolerance. We investigated 89 patients with nasal polyposis, 11 of whom had Aspirin-intolerance, 19 asthma and 22 allergies to inhalation allergens. HLA patterns of these patients were compared to the ones of 1,070 healthy controls. No significant association of HLA-A1B8 was found with nasal polyps in the Aspirin-sensitive subgroup of our patients, but a significant association was seen with HLA-A74 and nasal polyposis.
- Find related publications in this database (using NLM MeSH Indexing)
- Aspirin - adverse effects
- Asthma - diagnosis Asthma - genetics
- Drug Hypersensitivity - diagnosis Drug Hypersensitivity - genetics
- HLA Antigens - genetics
- HLA-A Antigens - genetics
- Humans -
- Nasal Polyps - diagnosis Nasal Polyps - genetics
- Nose Neoplasms - diagnosis Nose Neoplasms - genetics
- Phenotype -
- Risk Factors -
- Find related publications in this database (Keywords)
- nasal polyps
- pathogenesis
- HLA system