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Selected Publication:
Maier, A; Anegg, U; Fell, B; Rehak, P; Ratzenhofer, B; Tomaselli, F; Sankin, O; Pinter, H; Smolle-Jüttner, FM; Friehs, GB.
Hyperbaric oxygen and photodynamic therapy in the treatment of advanced carcinoma of the cardia and the esophagus.
Lasers Surg Med. 2000; 26(3):308-315
Doi: 10.1002/(SICI)1096-9101(2000)26:3<308::AID-LSM9>3.0.CO;2-B
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- Leading authors Med Uni Graz
- Maier Alfred
- Co-authors Med Uni Graz
- Anegg Udo
- Fell Birgit
- Pinter Hans
- Ratzenhofer-Komenda Beatrice
- Rehak Peter
- Sankin Oliver
- Smolle-Juettner Freyja-Maria
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- Abstract:
- BACKGROUND AND OBJECTIVE: The photochemical reaction of photodynamic therapy (PDT) depends on the presence of molecular oxygen. Because of anoxic regions in tumor tissue and vascular shutdown during PDT, the efficiency is limited. Therefore, the use of hyperbaric oxygen, which increases the oxygen in tumor tissue, as well as the amount of singlet oxygen, may enhance the efficiency of PDT. STUDY DESIGN/MATERIALS AND METHODS: After diagnostic work-up, photosensitization was carried out with a hematoporphyrin-derivate 2 mg/kg body weight 48 hours before PDT. The light dose was calculated as 300 J/cm of fiber tip. Twenty-three patients were treated by PDT alone and 29 patients received PDT under hyperbaric oxygen at a level of two absolute atmospheric pressures. RESULTS: Improvement regarding dysphagia and stenosis-diameter could be obtained in both treatment arms with no significant difference (P = 0.43 and P = 0. 065, respectively). The tumor length also decreased in both groups and showed a significant difference in favour of the PDT/HBO group (P = 0.002). The mean overall survival was 11.3 months. The mean survival time for the PDT group was 8.7 months and for the PDT/HBO group 13.8 months (P = 0.021). CONCLUSION: According to this pilot study, combined PDT/HBO represents a new approach in the treatment of esophageal and cardia cancer, which appears to have enhanced the efficiency of PDT.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Carcinoma - drug therapy
- Cardia - drug therapy
- Combined Modality Therapy - drug therapy
- Esophageal Neoplasms - drug therapy
- Female - drug therapy
- Follow-Up Studies - drug therapy
- Hematoporphyrin Photoradiation - methods
- Hematoporphyrins - methods
- Humans - methods
- Hyperbaric Oxygenation - methods
- Male - methods
- Photosensitizing Agents - therapeutic use
- Pilot Projects - therapeutic use
- Prospective Studies - therapeutic use
- Stomach Neoplasms - drug therapy
- Survival Analysis - drug therapy
- Find related publications in this database (Keywords)
- photodynamic therapy
- hyperbaric oxygenation
- esophageal carcinoma
- cardia carcinoma