Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Griesbacher, T; Althuber, P; Zenz, M; Rainer, I; Griengl, S; Lembeck, F.
Vespula vulgaris venom: role of kinins and release of 5-hydroxytryptamine from skin mast cells.
Eur J Pharmacol. 1998; 351(1):95-104
Doi: 10.1016/S0014-2999(98)00276-3
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- Führende Autor*innen der Med Uni Graz
- Griesbacher Thomas
- Co-Autor*innen der Med Uni Graz
- Lembeck Fred
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- Abstract:
- Wasp venoms contain several active components, among them kinin-related peptides. Like bradykinin and [Thr6]bradykinin, Vespula vulgaris venom caused paw oedema following subplantar injection in anaesthetized rats. The oedema was partly inhibited by the bradykinin B2 receptor antagonist icatibant (Hoe 140); the remaining part was abolished by additional pretreatment with 5-hydroxytryptamine (5-HT) receptor antagonists or mast cell depletion. Histamine receptor antagonists were ineffective. Capsaicin pretreatment attenuated oedema formation indicating a neurogenic sensory component. Nociceptive behavioural responses induced by the venom in unanaesthetized rats were abolished by icatibant. It is concluded that kinins, either contained in the venom or released from the tissue, play the predominant role in the inflammatory and algesic effects. The inflammatory effects only partly rely on direct, bradykinin receptor-mediated mechanisms while the remaining part depends on the release of 5-HT from skin mast cells. The algesic effects of the venom are entirely due to direct B2 receptor activation.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Anti-Inflammatory Agents, Non-Steroidal - administration and dosage
- Bradykinin - administration and dosage
- Capsaicin - therapeutic use
- Edema - chemically induced
- Female - chemically induced
- Histamine H1 Antagonists - administration and dosage
- Histamine H2 Antagonists - administration and dosage
- Injections, Intravenous - administration and dosage
- Injections, Subcutaneous - administration and dosage
- Kinins - analysis
- Mast Cells - drug effects
- Rats - drug effects
- Rats, Sprague-Dawley - drug effects
- Receptor, Bradykinin B2 - drug effects
- Receptors, Bradykinin - antagonists and inhibitors
- Serotonin - analysis
- Serotonin Antagonists - administration and dosage
- Skin - drug effects
- Wasp Venoms - chemistry
- Find related publications in this database (Keywords)
- Inflammation
- Bradykinin Receptor Antagonist
- Icatibant (Hoe 140)
- 5-HT (5-Hydroxytryptamine Serotonin) Release
- Pain
- Capsaicin