Medizinische Universität Graz - Research portal
Selected Publication:
Dornbusch, HJ; Urban, CE; Pinter, H; Ginter, G; Fotter, R; Becker, H; Miorini, T; Berghold, C.
Treatment of invasive pulmonary aspergillosis in severely neutropenic children with malignant disorders using liposomal amphotericin B (AmBisome), granulocyte colony-stimulating factor, and surgery: report of five cases.
Pediatr Hematol Oncol. 1995; 12(6):577-586
Doi: 10.3109/08880019509030772
(- Case Report)
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- Leading authors Med Uni Graz
- Dornbusch Hans Jürgen
- Co-authors Med Uni Graz
- Fotter Richard
- Pinter Hans
- Urban Ernst-Christian
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- Abstract:
- Five children with malignancies developed invasive pulmonary aspergillosis during chemotherapy-induced neutropenia. All patients were treated with liposomal amphotericin B and human recombinant granulocyte colony-stimulating factor. Two patients did not recover from bone marrow aplasia and died from organ-infiltrating fungal invasion. Two patients who recovered from bone marrow aplasia survived after surgery of the pulmonary lesions. The fifth patient had a complete resolution of invasive pulmonary aspergillosis after neutrophil recovery without surgical intervention. We conclude that not only the antifungal treatment but also the recovery of granulocytes are important in localizing invasive forms of Aspergillus infections in patients with profound immunosuppression.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Amphotericin B - administration and dosage
- Anti-Bacterial Agents - administration and dosage
- Antibiotics, Antifungal - administration and dosage
- Aspergillosis - drug therapy
- Child - drug therapy
- Child, Preschool - drug therapy
- Drug Carriers - drug therapy
- Female - drug therapy
- Granulocyte Colony-Stimulating Factor - administration and dosage
- Humans - administration and dosage
- Liposomes - administration and dosage
- Lung Diseases, Fungal - drug therapy
- Male - drug therapy
- Neoplasms - complications
- Neutropenia - complications