Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Horina, JH; Petritsch, W; Schmid, CR; Reicht, G; Wenzl, H; Silly, H; Krejs, GJ.
Treatment of anemia in inflammatory bowel disease with recombinant human erythropoietin: results in three patients.
Gastroenterology. 1993; 104(6):1828-1831
Doi: 10.1016/0016-5085(93)90666-Z
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- Führende Autor*innen der Med Uni Graz
- Horina Joerg
- Co-Autor*innen der Med Uni Graz
- Krejs Günter Josef
- Petritsch Wolfgang
- Sill Heinz
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- Abstract:
- Inflammatory bowel disease (IBD) is often associated with anemia. Of 85 patients with IBD, 28 were anemic and had an inadequately low plasma erythropoietin (EPO) concentration. Three patients with a long-standing history of IBD and refractory chronic anemia (hemoglobin values < 10 g/dL, plasma EPO concentrations below 100 mU/mL) were treated with recombinant human EPO, which was administered subcutaneously three times per week at a dose of 200-300 U/kg of body weight. Bone marrow biopsy specimens taken before therapy showed slightly decreased erythropoiesis with a shift of erythroid precursors toward more immature stages. EPO treatment resulted in a marked increase in hemoglobin values in all 3 patients. Bone marrow biopsies after EPO therapy showed quantitatively and qualitatively normal erythropoiesis in all of them. Correction of anemia was followed by improved well-being, and all patients were able to cope much better with their IBD. In all three patients, there was an increase in body weight and their Karnofsky index improved. After a complete workup and exclusion of any other cause for anemia, erythropoietin treatment, although expensive, should be considered in patients with IBD and refractory anemia.
- Find related publications in this database (using NLM MeSH Indexing)
- Anemia, Refractory - drug therapy Anemia, Refractory - etiology
- Bone Marrow - pathology
- Colitis, Ulcerative - complications
- Crohn Disease - complications
- Erythropoietin - blood Erythropoietin - therapeutic use
- Female -
- Humans -
- Male -
- Recombinant Proteins - therapeutic use