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Selected Publication:
Reiterer, EE; Zenz, W; Deutsch, J; Preisegger, KH; Simbrunner, J; Borkenstein, MH.
[Congenital hypopituitarism and giant cell hepatitis in a three month old girl].
Klin Padiatr. 2002; 214(3):136-139
Doi: 10.1055/s-2002-30150
(- Case Report)
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Fröhlich-Reiterer Elke
- Co-authors Med Uni Graz
- Borkenstein Helmuth Martin
- Deutsch Johann
- Simbrunner Josef
- Zenz Werner
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- Abstract:
- A three month old girl, with recurrent hypoglycemia and neonatal cholestasis, is reported. A metabolic disease could be excluded. The liver biopsy revealed giant cell hepatitis and intrahepatic bile duct hypoplasia. ACTH, Cortisol and hGH measured during hypoglycemia were low. Magnetic tomography (MR) of the brain showed an "empty sella". After beginning a replacement therapy with hydrocortisone, growth hormone and thyroxine there was no further episode of hypoglycemia. Transaminases and bilirubin levels normalized. The girl is in good condition, growth and development are normal. Hypoglycemia is often the first sign in childrens with neonatal hypopituitarism. The association of liver disease and hypopituitarism has been documented in a few reports. The pathophysiological mechanism leading to the liver dysfunction is not well understood. The prognosis of neonatal hypopituitarism as well as the concomitant liver disease is good under sufficient replacement therapy.
- Find related publications in this database (using NLM MeSH Indexing)
- Bile Ducts, Intrahepatic - abnormalities
- Bile Ducts, Intrahepatic - pathology
- Biliary Atresia - diagnosis
- Biliary Atresia - pathology
- Biopsy -
- Diagnosis, Differential -
- Empty Sella Syndrome - congenital
- Empty Sella Syndrome - diagnosis
- Empty Sella Syndrome - pathology
- Female -
- Giant Cells - pathology
- Hepatitis - congenital
- Hepatitis - diagnosis
- Hepatitis - pathology
- Humans -
- Hypopituitarism - congenital
- Hypopituitarism - diagnosis
- Hypopituitarism - pathology
- Infant -
- Liver - pathology
- Liver Function Tests -
- Magnetic Resonance Imaging -
- Pituitary Gland - abnormalities
- Pituitary Gland - pathology
- Find related publications in this database (Keywords)
- hypopituitarism
- giant cell hepatitis
- hypoglycemia