Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Schimpl, G; Pesendorfer, P; Steinwender, G; Feierl, G; Ratschek, M; Höllwarth, ME.
The effect of vitamin C and vitamin E supplementation on bacterial translocation in chronic portal hypertensive and common-bile-duct-ligated rats.
EUR SURG RES 1997 29: 187-194.
Doi: 10.1159/000129523
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Führende Autor*innen der Med Uni Graz
- Schimpl Guenther
- Co-Autor*innen der Med Uni Graz
- Feierl Gebhard
- Höllwarth Michael
- Ratschek Manfred
- Steinwender Gerhardt
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- In rats with chronic portal hypertension (PH) and common bile duct ligation (CBDL), significant ileal bacterial overgrowth, translocation of indigenous intestinal bacteria, a decrease in hepatic and ileal reduced glutathione (GSH) and an increase in ileal mucosal lipid peroxidation occur. alpha-Tocopherol (vitamin E) and ascorbic acid (vitamin C) treatment attenuated the incidence of bacterial translocation, improved hepatic and ileal GSH levels and decreased ileal mucosal lipid peroxidation. These results suggest that in chronic PH and CBDL oxidative processes in the liver and intestine play an important role for bacterial translocation.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Ascorbic Acid - pharmacology
- Bacterial Translocation - drug effects
- Biological Markers - analysis
- Cholestasis - microbiology
- Common Bile Duct - microbiology
- Glutathione - metabolism
- Hypertension, Portal - metabolism
- Ileum - metabolism
- Intestinal Mucosa - metabolism
- Lipid Peroxidation - drug effects
- Liver - metabolism
- Male - metabolism
- Rats - metabolism
- Rats, Sprague-Dawley - metabolism
- Vitamin E - pharmacology
- Find related publications in this database (Keywords)
- Bacterial Translocation
- Portal Hypertension
- Cholestatic Jaundice
- Alpha-Tocopherol
- Ascorbic Acid