Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Lind, P; Lechner, P; Arianschad, K; Binter, G; Klimpfinger, M; Langsteger, W; Koltringer, P; Kronberger, L; Cesnik, H; Kammerhuber, F; Eber, O.
Anti-CEA Immunoscintigraphy (Tc-99m Labeled Intact Igg1) and Serum CEA Levels in Colorectal-Cancer Care
ANTIBODY IMMUNOCONJ RADIOPHAR. 1991; 4: 545-552.
Web of Science
- Co-Autor*innen der Med Uni Graz
- Kapp Karin S.
- Kronberger Leo
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- Abstract:
- With the introduction of Tc-99m labeled monoclonal antibodies against carcinoembryonic antigen (CEA), a clinically relevant progress can be expected in the diagnosis of colorectal carcinomas by immunoscintigraphy (IS). In 161 patients (primary colorectal carcinomas [PCC], occult neoplasms and suspected colorectal recurrences [CR]), we performed IS with 1 mg of a Tc-99m labeled intact murine anti-CEA antibody (BW 431/26). Whole body scans were done 5 1/2 and SPECT of the abdominal region 6 and 24 hours post injection of 1100 MBq Tc-99m labeled MAb. In suspected PCC (n = 75), almost all surgically verified carcinomas (n = 53) were confirmed and correctly localized by IS (sensitivity 94%, specificity 91%). In suspected CR (n = 86), IS showed a sensitivity of 95% and a specificity of 85%. Especially in patients in whom transmission computed tomography (TCT) failed to differentiate clearly between scar and recurrence, IS was the method of choice to clarify the problem. Human anti-mouse antibodies were found in about 30%. From the 53 surgically verified PCC serum CEA was elevated in only 25 cases and in the normal range in 28 cases. Serum CEA in patients with CR was elevated in only 21 out of 38 patients. According to our clinical experience with this Tc-99m labeled monoclonal antibody, anti-CEA IS plays a pre-eminent role in the exclusion or identification of colorectal recurrences.