Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Kaufmann, P; Smolle, KH; Brunner, GA; Demel, U; Tilz, GP; Krejs, GJ.
Relation of serial measurements of plasma-soluble intercellular adhesion molecule-1 to severity of acute pancreatitis.
Am J Gastroenterol. 1999; 94(9):2412-2416
Doi: 10.1111/j.1572-0241.1999.01366.x
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- Co-Autor*innen der Med Uni Graz
- Brunner Gernot
- Demel Ulrike
- Krejs Günter Josef
- Smolle Karl-Heinz
- Tilz Gernot
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- Abstract:
- OBJECTIVE: Acute pancreatitis remains a clinical challenge because it is difficult to predict whether, in a given patient, the disease will be mild or will run a severe course with a possibly fatal outcome. The aim of this study was to investigate whether circulating soluble intercellular adhesion molecule-1 (sICAM-1) as a marker of leukocyte activation is related to the severity of the disease. METHODS: The study included 29 consecutive adults admitted with acute pancreatitis. Plasma sICAM-1 levels were measured serially over a period of 6 days, and values and time courses were correlated with clinical severity. RESULTS: Our patients fell into four groups on the basis of the following measurements: 1) Decreasing sICAM-1 levels with maximal values of 446 +/- 90 ng/ml (mean +/- SEM) slightly above the upper limit of normal were associated with uncomplicated mild disease in seven patients. 2) In nine patients with sICAM-1 concentrations reaching a peak of 743 +/- 121 ng/ml after 3 days, severe pancreatitis was present in 11% and pancreatic necrosis occurred in 33%. 3) A second increase of sICAM-1 (maximal level: 993 +/- 169 ng/ml) after an initial decrease (relapsing pattern, 7 patients) was associated with a severe course of disease in 71% including pancreatic necrosis in 43% and nosocomial pneumonia in 42%. 4) A rapid increase of sICAM-1 reaching highest maximal values of 1738 +/- 104 ng/ml (p < 0.0001) indicated fulminant pancreatic necrosis and a fatal outcome in six patients. CONCLUSIONS: Serial plasma sICAM-1 levels in patients with acute pancreatitis within the first 6 days after admission fall into four different groups of severity according to the shape of the curves. This suggests that the time course of elevated plasma sICAM-1 concentrations reflects the risk of developing necrosis and clinical complications in acute pancreatitis. (Am J Gastroenterol 1999;94:2412-2416 (C) 1999 by Am. Cell. of Gastroenterology).
- Find related publications in this database (using NLM MeSH Indexing)
- Acute Disease -
- Female -
- Humans -
- Intercellular Adhesion Molecule-1 - blood
- Male -
- Middle Aged -
- Pancreatitis - blood
- Prospective Studies -
- Severity of Illness Index -