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SHR Neuro Cancer Cardio Lipid Metab Microb

Tomelleri, A; Dejaco, C; Bond, M.
To prophylax or not to prophylax? The role of trimethoprim/ sulfamethoxazole as a prophylactic agent in systemic vasculitis: the case of antineutrophil cytoplasmic antibody-associated vasculitis and giant cell arteritis
REUMATISMO. 2025; 77(2): 1791 Doi: 10.4081/reumatismo.2025.1791
Web of Science PubMed FullText FullText_MUG

Co-authors Med Uni Graz: Dejaco Christian
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Abstract:: Inflammatory rheumatic and musculoskeletal diseases, including systemic vasculitis, increase the risk of infection due to immunosuppressive treatments and disease-related immune dysfunction. In this viewpoint, we focused on patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV) and giant cell arteritis (GCA). We critically reviewed the literature on infectious risks and the role of trimethoprim/sulfamethoxazole (TMP/SMX) as a prophylactic agent in these conditions. In AAV, serious infections from opportunistic (e.g., Pneumocysfis jirovecii) and non-opportunistic pathogens are especially common, peaking in the first year post-diagnosis. TMP/SMX is crucial for prevenalthough the risk of PJP is low, the overall infection risk is high and ing the routine use of TMP/SMX in GCA is limited, warranting further investigation through randomized clinical trials.
Find related publications in this database (Keywords): vasculitis; infections; trimethoprim-sulfamethoxazole; prophylaxis; Pneumocysfis jirovecii