Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Tawfik, I; Schlick, K; Ostaku, J; Bresilla, D; Gabrijelčič, S; Gottschalk, B; Sokolowski, A; Malle, E; Kalinova, K; Hirtl, M; Madreiter-Sokolowski, CT.
Breast cancer cells utilize T3 to trigger proliferation through cellular Ca2+ modulation.
Cell Commun Signal. 2024; 22(1): 533
Doi: 10.1186/s12964-024-01917-y
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- Leading authors Med Uni Graz
- Madreiter-Sokolowski Corina
- Tawfik Ines
- Co-authors Med Uni Graz
- Bresilla Doruntina
- Gottschalk Benjamin
- Hirtl Martin
- Kalinova Katarina
- Malle Ernst
- Ostaku Julian
- Schlick Katharina
- Sokolowski Alwin
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- Abstract:
- High levels of thyroid hormones are linked to increased risk and advanced stages of breast cancer. Our previous work demonstrated that the biologically active triiodothyronine (T3) facilitates mitochondrial ATP production by upregulating Ca2+ handling proteins, thereby boosting mitochondrial Ca2+ uptake and Krebs cycle activity. In this study, different cell types were utilized to investigate whether T3 activates a Ca2+-induced signaling pathway to boost cancer cell proliferation. Using live-cell imaging, biochemical assays, and molecular profiling, differences in intracellular signaling among MCF7 and MDA-MB-468 breast cancer cells, non-cancerous breast cells hTERT-HME1, and PC3 prostate carcinoma cells, previously found to be insensitive to thyroid hormones in terms of proliferation, were investigated. Our findings revealed that T3 upregulates 1,4,5-trisphosphate receptor 3 via thyroid hormone receptor α. This boosts mitochondrial Ca2+ uptake, reduction equivalent yield, and mitochondrial ATP production, supporting the viability and proliferation of breast cancer cells without affecting non-cancerous hTERT-HME1 or PC3 prostate carcinoma cells. Understanding the interplay between T3 signaling, organellar interaction, and breast cancer metabolism could lead to targeted therapies that exploit cancer cell vulnerabilities. Our findings highlight T3 as a crucial regulator of cancer metabolism, reinforcing its potential as a therapeutic target in breast cancer.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Cell Proliferation - administration & dosage
- Breast Neoplasms - metabolism, pathology
- Calcium - metabolism
- Triiodothyronine - metabolism, pharmacology
- Mitochondria - metabolism
- Female - administration & dosage
- Cell Line, Tumor - administration & dosage
- Inositol 1,4,5-Trisphosphate Receptors - metabolism
- Adenosine Triphosphate - metabolism
- Calcium Signaling - administration & dosage
- Find related publications in this database (Keywords)
- Thyroid hormones
- Calcium homeostasis
- Breast cancer
- Mitochondria
- Thyroid hormone receptor alpha