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SHR Neuro Cancer Cardio Lipid Metab Microb

Polzer, C; Kurath-Koller, S; Danci, D; Simma, B; Resch, B.
Microbiome research in neonatology-Prevention with probiotics/prebiotics?
MONATSSCHR KINDERH. 2024; Doi: 10.1007/s00112-024-02015-6
Web of Science FullText FullText_MUG

Co-authors Med Uni Graz: Kurath-Koller Stefan; Resch Bernhard
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Abstract:: BackgroundThe intestinal microbiome fulfils a variety of tasks in the human body. Changes in the colonization of the intestine and the composition of the microbiome in neonates can be seen in connection with the development of diseases. The intestinal microbes also play a leading role in necrotizing enterocolitis. The association between the development and composition of the intestinal microbiome in the neonates, in premature infants and in patients who develop necrotizing enterocolitis, suggests promising approaches for the prevention of necrotizing enterocolitis. ObjectiveThe aim of the study is to provide insights into the current state of research and to show the possibilities in the prevention of necrotizing enterocolitis with the help of prebiotics and probiotics. Material and methodsThe PubMed database was used for the literature search. The keywords "intestinal microbiome OR microbiota OR gut microbiota AND infants AND necrotizing enterocolitis AND probiotic OR probiotics" were used to search for recent meta-analyses and systematic reviews. The included articles were then supplemented using a snowball search (forward and backward search). Results and conclusionThe current literature contains studies that show the benefits of probiotics in relation to necrotizing enterocolitis. Due to the heterogeneity of the individual studies, the optimal dose and administration of probiotics is still the subject of research. The administration of several strains (lactobacilli and bifidobacteria) in addition to other measures (type of nutrition, responsible use of antibiotics and hygiene measures) appear to be very promising.
Find related publications in this database (Keywords): Intestinal microbiome; Preterm infant; Necrotizing enterocolitis; Breast milk; Antibiotics; Intestinal microbiome; Preterm infant; Necrotizing enterocolitis; Breast milk; Antibiotics