Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Herrmann, M; Keppel, MH; Zelzer, S; Alonso, N; Cavalier, E; Kleber, M; Enko, D; Scharnagl, H; Pilz, S; März, W.
The role of functional vitamin D deficiency and low vitamin D reservoirs in relation to cardiovascular health and mortality.
Clin Chem Lab Med. 2025; 63(1):208-219 Doi: 10.1515/cclm-2024-0391
Web of Science PubMed FullText FullText_MUG

Leading authors Med Uni Graz: Herrmann Markus
Co-authors Med Uni Graz: Alonso Lopez Nerea; Enko Dietmar; Keppel Martin Helmut; März Winfried; Pilz Stefan; Scharnagl Hubert; Zelzer Sieglinde
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: OBJECTIVES: The role of vitamin D deficiency in cardiovascular disease (CVD) is controversial. Inherent biological and analytical limitations compromise the specificity of widely used 25-hydroxyvitamin D [25(OH)D] cut-offs. Simultaneous determination of 25(OH)D and 24,25-dihydroxyvitamin D [24,25(OH)₂D] permits a functional assessment of vitamin D metabolism. The present study compared the associations of functional vitamin D deficiency and low vitamin D reservoirs with CVD mortality and CVD burden. METHODS: 25(OH)D, 24,25(OH)₂D, the degree of coronary obstruction on angiography, high-sensitive cardiac troponin T (hs-cTnT), N-terminal brain natriuretic peptide (NT-proBNP), and 10-year CVD mortality were obtained from 2,456 participants of the LURIC (Ludwigshafen Risk and Cardiovascular Health) study. RESULTS: Neither low 25(OH)D concentrations nor functional vitamin D deficiency were associated with the number of atherosclerotic coronary arteries or the degree of coronary obstruction. Over a median follow-up of 9.9 years, 454 participants died (23.6 %) due to CVD. CVD mortality was doubled in individuals with 25(OH)D concentrations below the widely used cut-off for deficiency of <50 nmol/L [20 ng/mL] (21.6 vs. 11.5 %). In individuals with and without functional vitamin D deficiency, CVD mortality was 25.0 and 16.7 %, respectively. NT-proBNP and heart failure prevalence were also higher in vitamin D deficient individuals. CONCLUSIONS: Vitamin D deficient individuals have markedly higher CVD mortality, but only marginally higher hs-cTnT concentrations. A higher prevalence of heart failure and higher NT-proBNP concentrations suggest a link between vitamin D deficiency and cardiac function. The traditional and metabolic assessment of vitamin D status showed comparable associations for the different parameters of cardiac health.
Find related publications in this database (using NLM MeSH Indexing): Humans - administration & dosage; Vitamin D Deficiency - blood, complications, epidemiology; Male - administration & dosage; Vitamin D - blood, analogs & derivatives; Female - administration & dosage; Middle Aged - administration & dosage; Cardiovascular Diseases - mortality, blood; Aged - administration & dosage; Natriuretic Peptide, Brain - blood; Peptide Fragments - administration & dosage
Find related publications in this database (Keywords): vitamin D; functional deficiency; cardiovascular mortality