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SHR Neuro Cancer Cardio Lipid Metab Microb
Kreuzer, K; Birkl-Toeglhofer, AM; Haybaeck, J; Reiter, A; Dalkner, N; Fellendorf, FT; Maget, A; Platzer, M; Seidl, M; Mendel, LM; Lenger, M; Birner, A; Queissner, R; Mairinger, M; Obermayer, A; Kohlhammer-Dohr, A; Stross, TM; Häussl, A; Hamm, C; Schöggl, H; Amberger-Otti, D; Painold, A; Lahousen-Luxenberger, T; Leitner-Afschar, B; Färber, T; Mörkl, S; Wagner-Skacel, J; Meier-Allard, N; Lackner, S; Holasek, S; Habisch, H; Madl, T; Reininghaus, E; Bengesser, SA.
PROVIT-CLOCK: A Potential Influence of Probiotics and Vitamin B7 Add-On Treatment and Metabolites on Clock Gene Expression in Major Depression.
Neuropsychobiology. 2024; 83(3-4):135-151
Doi: 10.1159/000538781
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- Leading authors Med Uni Graz
- Kreuzer Kathrin
- Madl Tobias
- Co-authors Med Uni Graz
- Amberger-Otti Daniela
- Bengesser Susanne
- Birkl-Töglhofer Anna Maria
- Birner Armin
- Dalkner Nina
- Fellendorf Frederike
- Habisch Hansjörg
- Hamm Carlo
- Häussl Alfred Alois
- Haybäck Johannes
- Holasek Sandra Johanna
- Kohlhammer-Dohr Alexandra
- Lackner Sonja
- Lahousen-Luxenberger Theresa
- Leal Garcia Sabrina
- Lenger Melanie
- Maget Alexander
- Mairinger Marco
- Meier-Allard Nathalie
- Painold Annamaria
- Platzer Martina
- Queissner Robert
- Ramirez-Obermayer Anna Maria Antonia
- Reininghaus Eva
- Schöggl Helmut
- Seidl Matthias
- Stross Tatjana Maria
- Wagner-Skacel Jolana
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- Abstract:
- INTRODUCTION: An increasing body of evidence suggests a strong relationship between gut health and mental state. Lately, a connection between butyrate-producing bacteria and sleep quality has been discussed. The PROVIT study, as a randomized, double-blind, 4-week, multispecies probiotic intervention study, aims at elucidating the potential interconnection between the gut's metabolome and the molecular clock in individuals with major depressive disorder (MDD). METHODS: The aim of the PROVIT-CLOCK study was to analyze changes in core clock gene expression during treatment with probiotic intervention versus placebo in fasting blood and the connection with the serum- and stool-metabolome in patients with MDD (n = 53). In addition to clinical assessments in the PROVIT study, metabolomics analyses with 1H nuclear magnetic resonance spectroscopy (stool and serum) and gene expression (RT-qPCR) analysis of the core clock genes ARNTL, PER3, CLOCK, TIMELESS, NR1D1 in peripheral blood mononuclear cells of fasting blood were performed. RESULTS: The gene expression levels of the clock gene CLOCK were significantly altered only in individuals receiving probiotic add-on treatment. TIMELESS and ARNTL gene expression changed significantly over the 4-week intervention period in both groups. Various positive and negative correlations between metabolites in serum/stool and core clock gene expression levels were observed. CONCLUSION: Changing the gut microbiome by probiotic treatment potentially influences CLOCK gene expression. The preliminary results of the PROVIT-CLOCK study indicate a possible interconnection between the gut microbiome and circadian rhythm potentially orchestrated by metabolites.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Probiotics - pharmacology, administration & dosage
- Depressive Disorder, Major - therapy, metabolism, blood, drug therapy
- Double-Blind Method - administration & dosage
- Adult - administration & dosage
- Male - administration & dosage
- Female - administration & dosage
- Middle Aged - administration & dosage
- CLOCK Proteins - genetics
- Gastrointestinal Microbiome - physiology, drug effects
- Gene Expression - drug effects
- Metabolome - drug effects
- Feces - microbiology, chemistry
- Find related publications in this database (Keywords)
- Major depressive disorder
- Gut-brain axis
- Circadian clock genes
- Randomized controlled trial