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SHR Neuro Cancer Cardio Lipid Metab Microb

Weitzer, F; Stanzel, S; Plhak, E; Aigner, RM.
Clinical value of semi-quantitative parameters in ⁶⁸Ga-DOTANOC PET/CT in treatment and diagnostics of cranial meningioma in a single-center retrospective analysis.
EJNMMI Rep. 2024; 8(1): 13 Doi: 10.1186/s41824-024-00204-w [OPEN ACCESS]
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Leading authors Med Uni Graz: Weitzer Friedrich
Co-authors Med Uni Graz: Aigner Reingard; Plhak Elisabeth; Stanzel Susanne
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Abstract:: BACKGROUND: The value of somatostatin-analogon PET tracers in theranostics in cranial meningioma has been demonstrated in several studies however, the value of semi-quantitative parameters for therapy and patient outcome is still unclear. METHODS: A retrospective study was performed comparing measured semi-quantitative ⁶⁸Ga-DOTANOC PET/CT parameters (maximum standardized uptake value = SUVmax, mean standardized uptake value = SUVmean, and metabolic tumor volume = MTV) and calculated ratios (SUVmax tumor/to pituitary gland, SUVmax tumor to superior sinus sagittalis), versus WHO grades and overall outcome. Patients with histological confirmed meningioma or high probability for meningioma in previous cranial MRI were eligible. RESULTS: Thirty-two patients from January 2018 to February 2023 were retrospectively included. WHO grade I meningioma was confirmed in 17 patients, WHO grade II in five patients, WHO grade III in two patients, while in eight patients diagnosis was solely based on MRI and ⁶⁸Ga-DOTANOC PET/CT findings. In 12 cases stable disease was present, in 15 cases radiation therapy was chosen, in three cases neurosurgery was preferred while in two cases palliative care was chosen. Median SUVmax values increased with WHO grade (15.84, 17.22, and 28.4, p = 0.134, Kruskal-Wallis-test) and no statistically significant difference was present for MTV, SUVmax, and calculated ratios, although the ratio for SUVmax tumor to superior sinus sagittalis had the lowest value of p = 0.067. CONCLUSION: Increased SUVmax values in the tumor in ⁶⁸Ga-DOTANOC PET/CT are associated with higher WHO grade, although further studies including larger patient collectives are needed to solidify this hypothesis.
Find related publications in this database (Keywords): Ga-68-DOTANOC; Meningioma; Semi-quantitative parameters; PET/CT