Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Eichinger, M; Shah, K; Palt, N; Eichlseder, M; Pichler, A; Zoidl, P; Zajic, P; Rief, M.
Association of prehospital lactate levels with base excess in various emergencies - a retrospective study.
Clin Chem Lab Med. 2024; 62(8):1602-1610
Doi: 10.1515/cclm-2024-0060
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Eichinger Michael
- Rief Martin
- Co-authors Med Uni Graz
- Eichlseder Michael
- Pichler Alexander
- Zajic Paul
- Zoidl Philipp
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- Abstract:
- OBJECTIVES: Blood gas analysis, including parameters like lactate and base excess (BE), is crucial in emergency medicine but less commonly utilized prehospital. This study aims to elucidate the relationship between lactate and BE in various emergencies in a prehospital setting and their prognostic implications. METHODS: We conducted a retrospective analysis of prehospital emergency patients in Graz, Austria, from October 2015 to November 2020. Our primary aim was to assess the association between BE and lactate. This was assessed using Spearman's rank correlation and fitting a multiple linear regression model with lactate as the outcome, BE as the primary covariate of interest and age, sex, and medical emergency type as confounders. RESULTS: In our analysis population (n=312), lactate and BE levels were inversely correlated (Spearman's ρ, -0.75; p<0.001). From the adjusted multiple linear regression model (n=302), we estimated that a 1 mEq/L increase in BE levels was associated with an average change of -0.35 (95 % CI: -0.39, -0.30; p<0.001) mmol/L in lactate levels. Lactate levels were moderately useful for predicting mortality with notable variations across different emergency types. CONCLUSIONS: Our study highlights a significant inverse association between lactate levels and BE in the prehospital setting, underscoring their importance in early assessment and prognosis in emergency care. Additionally, the findings from our secondary aims emphasize the value of lactate in diagnosing acid-base disorders and predicting patient outcomes. Recognizing the nuances in lactate physiology is essential for effective prehospital care in various emergency scenarios.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Retrospective Studies - administration & dosage
- Female - administration & dosage
- Lactic Acid - blood
- Male - administration & dosage
- Middle Aged - administration & dosage
- Aged - administration & dosage
- Emergency Medical Services - administration & dosage
- Adult - administration & dosage
- Aged, 80 and over - administration & dosage
- Emergencies - administration & dosage
- Linear Models - administration & dosage
- Blood Gas Analysis - administration & dosage
- Prognosis - administration & dosage
- Find related publications in this database (Keywords)
- emergency medical services
- blood gas analysis
- lactic acid
- acid-base imbalance