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SHR Neuro Cancer Cardio Lipid Metab Microb
Jäger, M; Sonnleitner, ST; Dichtl, S; Lafon, E; Diem, G; Walder, G; Lass-Flörl, C; Wilflingseder, D; Posch, W.
Immune Responses Against SARS-CoV-2 WT and Delta Variant in Elderly BNT162b2 Vaccinees.
Front Immunol. 2022; 13:868361
Doi: 10.3389/fimmu.2022.868361
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- Leading authors Med Uni Graz
- Lamprecht-Sonnleitner Sissy Therese
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- Abstract:
- BACKGROUND: Residents of nursing homes are one of the most vulnerable groups during the severe acute syndrome coronavirus 2 (SARS-CoV-2) pandemic. The aim of this study was to characterize cellular and humoral immune responses in >70-year-old participants before vaccination, after first and second vaccination with BNT162b2, in contrast to second-dose-vaccinated participants younger than 60 years. METHODS: Peripheral blood mononuclear cells of 45 elderly and 40 younger vaccinees were analyzed by IFNγ ELISpot, specific immunoglobulin G antibody titers against SARS-CoV-2 spike protein, and neutralization abilities against SARS-CoV-2 wild-type (WT) and Delta variant (B.1.617.2). RESULTS: Our results clearly demonstrate a significantly increased T cell response, IgG titers, and neutralization activities against SARS-CoV-2 WT and Delta between first and second vaccination with BNT162b2 in elderly vaccinees, thereby highlighting the importance of the second booster. Interestingly, similar cellular and humoral immune responses against SARS-CoV-2 WT and Delta were found after the second vaccine dose in the young and elderly groups. CONCLUSIONS: Our data demonstrate a full picture of cellular and humoral immune responses of BNT162b2-vaccinees in two age cohorts. In all vaccines, SARS-CoV-2 WT-specific antibodies with similar neutralizing activity were detected in all vaccinees. After the second vaccination, neutralization titers against SARS-CoV-2 Delta were impaired in both age groups compared with SARS-CoV-2 WT, thereby emphasizing the need for an additional booster to overcome rising variants of SARS-CoV-2.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged - administration & dosage
- Antibodies, Viral - administration & dosage
- BNT162 Vaccine - administration & dosage
- COVID-19 - administration & dosage
- Humans - administration & dosage
- Immunity, Humoral - administration & dosage
- Leukocytes, Mononuclear - administration & dosage
- SARS-CoV-2 - administration & dosage
- Spike Glycoprotein, Coronavirus - administration & dosage
- Viral Vaccines - administration & dosage
- Find related publications in this database (Keywords)
- Age-dependent immune responses after BNT162b2
- SARS-CoV-2 vaccination
- T cell immunity
- neutralizing antibodies
- SARS-CoV-2
- variants of concern (VOCs)
- COVID-19
- virus neutralization