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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Sonnleitner, ST; Prelog, M; Jansen, B; Rodgarkia-Dara, C; Gietl, S; Schönegger, CM; Koblmüller, S; Sturmbauer, C; Posch, W; Almanzar, G; Jury, H; Loney, T; Tichy, A; Nowotny, N; Walder, G.
Maintenance of neutralizing antibodies over ten months in convalescent SARS-CoV-2 afflicted patients.
Transbound Emerg Dis. 2022; 69(3):1596-1605
Doi: 10.1111/tbed.14130
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- Leading authors Med Uni Graz
- Lamprecht-Sonnleitner Sissy Therese
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- Abstract:
- Knowledge of the level and duration of protective immunity against SARS-CoV-2 after primary infection is of crucial importance for preventive approaches. Currently, there is a lack of evidence on the persistence of specific antibodies. We investigated the generation and maintenance of neutralizing antibodies of convalescent SARS-CoV-2-afflicted patients over a ten-month period post-primary infection using an immunofluorescence assay, a commercial chemiluminescent immunoassay and an in-house enzyme-linked neutralization assay. We present the successful application of an improved version of the plaque-reduction neutralization assay which can be analysed optometrically to simplify data interpretation. Based on the results of the enzyme-linked neutralization assay, neutralizing antibodies were maintained in 77.4% of convalescent individuals without relevant decay over ten months. Furthermore, a positive correlation between severity of infection and antibody titre was observed. In conclusion, SARS-CoV-2-afflicted individuals have been proven to be able to develop and maintain neutralizing antibodies over a period of ten months after primary infection. Findings suggest long-lasting presumably protective humoral immune responses after wild-type infection.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals - administration & dosage
- Antibodies, Neutralizing - administration & dosage
- Antibodies, Viral - administration & dosage
- COVID-19 - veterinary
- Immunity, Humoral - administration & dosage
- SARS-CoV-2 - administration & dosage
- Find related publications in this database (Keywords)
- IgG antibodies
- immunity
- neutralization test
- persistence
- SARS-CoV-2