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Selected Publication:
Mächler, H; Metzler, H; Sabin, K; Anelli-Monti, M; Rehak, P; Rigler, B; Gombotz, H.
Preoperative myocardial cell damage in patients with unstable angina undergoing coronary artery bypass graft surgery.
Anesthesiology. 1994; 81(6):1324-1331
Doi: 10.1097/00000542-199412000-00005
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- Leading authors Med Uni Graz
- Mächler Heinrich
- Co-authors Med Uni Graz
- Anelli-Monti Michael
- Metzler Helfried
- Rehak Peter
- Rigler Bruno
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- Abstract:
- Troponin-T is one of the contractile proteins of the myocardium. Its release into the circulation indicates various degrees of myocardial cell damage. Troponin-T may be measured in serum with a recently developed enzyme immunoassay. This immunoassay was used to evaluate the preoperative myocardial cell damage in patients with stable and unstable angina undergoing elective coronary artery bypass graft surgery, and it was compared with conventional assays of creatine kinase (CK) MB isoenzyme activity and mass. Twenty-one patients with unstable angina and 31 with stable angina were studied. Troponin-T, CK-MB activity, and CK-MB mass were measured 24 h before anesthesia and surgery, immediately before induction of anesthesia, before and after cardiopulmonary bypass, at the end of surgery, and 24 h afterward. In 90% (19 of 21) of the patients with unstable angina, troponin-T was increased 24 h before anesthesia (median 0.33 microgram/l, range 0.15-5.2 micrograms/l), whereas only 3% (1 of 31) of the patients with stable angina had increased values (median 0.0 microgram/l, range 0.0-0.53 microgram/l). The difference was statistically significant (P < 0.001). The same profile was found in patients with and without unstable angina immediately before induction of anesthesia (86% [18 of 21] and 0%, respectively) and before cardiopulmonary bypass (62% [13 of 21] and 0%, respectively). In contrast to troponin-T, CK-MB activity was increased in only 0-14% of patients with unstable angina, and CK-MB mass was increased in only 9-24%. After bypass troponin-T increased in both groups (P < 0.01), but there was no longer a statistically significant difference between the groups. Twelve percent (4 of 31) of the patients in the stable angina group and 28% (6 of 21) in the unstable group had major cardiac events (P not significant). The study data suggest that many patients with unstable angina undergoing elective coronary artery bypass graft surgery have already increased troponin-T levels preoperatively, although conventional biochemical markers such as CK-MB activity and mass are at a normal range. Increased troponin-T and normal CK-MB concentrations may reflect some degree of ischemic myocardial cell damage. Because of the small number of patients in the study, the influence of preoperative myocardial injury on perioperative outcome could not be clarified.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Angina, Unstable - blood Angina, Unstable - enzymology Angina, Unstable - pathology
- Biological Markers -
- Coronary Artery Bypass -
- Creatine Kinase - metabolism
- Electrocardiography -
- Enzyme-Linked Immunosorbent Assay -
- Female -
- Humans -
- Intraoperative Complications - diagnosis
- Isoenzymes -
- Isoflurane -
- Male -
- Middle Aged -
- Myocardial Infarction - diagnosis
- Myocardium - pathology
- Preanesthetic Medication -
- Preoperative Care -
- Prognosis -
- Troponin - blood
- Troponin T -
- Find related publications in this database (Keywords)
- Heart
- Perioperative Myocardial Cell Damage
- Troponin-T
- Surgery
- Cardiac
- Coronary Artery Bypass Graft