Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Nonn, O; Bonstingl, L; Sallinger, K; Neuper, L; Fuchs, J; Gauster, M; Huppertz, B; Brislinger, D; El-Heliebi, A; Fluhr, H; Kampelmühler, E; Klaritsch, P.
Maternal COVID-19 causing intrauterine foetal demise with microthrombotic placental insufficiency: a case report.
BMC Pregnancy Childbirth. 2023; 23(1): 653
Doi: 10.1186/s12884-023-05942-6
(- Case Report)
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- Leading authors Med Uni Graz
- Nonn Olivia
- Co-authors Med Uni Graz
- Bonstingl Lilli
- Brislinger Dagmar
- El-Heliebi Amin
- Fluhr Herbert
- Fuchs Julia
- Gauster Martin
- Huppertz Berthold
- Kampelmühler Eva
- Klaritsch Philipp
- Neuper Lena
- Sallinger Katja
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- Abstract:
- BACKGROUND: Pregnant women have an increased risk of getting infected with SARS-CoV-2 and are more prone to severe illness. Data on foetal demise in affected pregnancies and its underlying aetiology is scarce and pathomechanisms remain largely unclear. CASE: Herein we present the case of a pregnant woman with COVID-19 and intrauterine foetal demise. She had no previous obstetric or gynaecological history, and presented with mild symptoms at 34 + 3 weeks and no signs of foetal distress. At 35 + 6 weeks intrauterine foetal death was diagnosed. In the placental histopathology evaluation, we found inter- and perivillous fibrin depositions including viral particles in areas of degraded placental anatomy without presence of viral entry receptors and SARS-CoV-2 infection of the placenta. CONCLUSION: This case demonstrates that maternal SARS-CoV-2 infection in the third trimester may lead to an unfavourable outcome for the foetus due to placental fibrin deposition in maternal COVID-19 disease possibly via a thrombogenic microenvironment, even when the foetus itself is not infected.
- Find related publications in this database (using NLM MeSH Indexing)
- Pregnancy - administration & dosage
- Female - administration & dosage
- Humans - administration & dosage
- Placental Insufficiency - etiology
- COVID-19 - complications
- Placenta - administration & dosage
- SARS-CoV-2 - administration & dosage
- Stillbirth - administration & dosage
- Fibrin - administration & dosage
- Find related publications in this database (Keywords)
- SARS-CoV-2-Infection
- COVID-19
- Vertical transmission
- Intrauterine foetal death
- In situ detection
- Perivillous fibrin deposition and chronic placentitis
- Pregnancy
- Microthrombosis
- Case report