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SHR Neuro Cancer Cardio Lipid Metab Microb

Kiessling, M; Djalinac, N; Voglhuber, J; Ljubojevic-Holzer, S.
Nuclear Calcium in Cardiac (Patho)Physiology: Small Compartment, Big Impact.
Biomedicines. 2023; 11(3): Doi: 10.3390/biomedicines11030960 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Leading authors Med Uni Graz: Holzer Senka; Kießling Mara Luisa
Co-authors Med Uni Graz: Voglhuber Julia
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Abstract:: The nucleus of a cardiomyocyte has been increasingly recognized as a morphologically distinct and partially independent calcium (Ca²⁺) signaling microdomain, with its own Ca²⁺-regulatory mechanisms and important effects on cardiac gene expression. In this review, we (1) provide a comprehensive overview of the current state of research on the dynamics and regulation of nuclear Ca²⁺ signaling in cardiomyocytes, (2) address the role of nuclear Ca²⁺ in the development and progression of cardiac pathologies, such as heart failure and atrial fibrillation, and (3) discuss novel aspects of experimental methods to investigate nuclear Ca²⁺ handling and its downstream effects in the heart. Finally, we highlight current challenges and limitations and recommend future directions for addressing key open questions.
Find related publications in this database (Keywords): nuclear calcium; excitation-contraction coupling; excitation-transcription coupling; cardiac remodeling; heart failure; atrial fibrillation