Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Wirnsberger, GH; Ratschek, M; Dimai, HP; Holzer, H; Mandal, AK.
Post-transplantation lymphoproliferative disorder of the T-cell/B-cell type: an unusual manifestation in a renal allograft.
ONCOL REP. 1998; 6(1): 29-32.
(- Case Report)
Web of Science
PubMed
- Führende Autor*innen der Med Uni Graz
- Wirnsberger Gerhard
- Co-Autor*innen der Med Uni Graz
- Dimai Hans Peter
- Holzer Herwig
- Ratschek Manfred
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- Abstract:
- Marked impairment of the cellular immune system predisposes renal transplant recipients to Epstein-Barr virus (EBV) associated clinical syndromes. This can culminate in post-transplantation lymphoproliferative disorders (PTLD) and malignant lymphomas. An unusual PTLD in a 59-year-old renal transplant recipient is reported here. Sonography and CT scan revealed a hypovascular infiltrating tumor mass in the lower pole of the graft which on histopathologic examination revealed a monotonous lymphoid proliferation. T-cell receptor and immunoglobulin heavy chain gene rearrangement as well as immunohistochemical analyses demonstrated a polyclonal origin of atypical lymphatic T- and B-cells. The Epstein-Barr viral genome was detected in the mass by Southern blot analysis, and a primary EBV infection was confirmed by serologic studies. Clinical follow-up showed a tumor-free course till the patient's sudden cardiac death 14 months after the operation.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- B-Lymphocytes - pathology
- Contact Tracing - pathology
- Cytomegalovirus Infections - complications
- Epstein-Barr Virus Infections - complications
- Graft Rejection - drug therapy
- Herpes Simplex - complications
- Herpesvirus 4, Human - isolation and purification
- Humans - isolation and purification
- Immunosuppression - adverse effects
- Kidney Neoplasms - etiology
- Kidney Transplantation - adverse effects
- Lymphoma, Mixed-Cell - etiology
- Male - etiology
- Middle Aged - etiology
- Nephrectomy - etiology
- Postoperative Complications - etiology
- Pyelonephritis - surgery
- T-Lymphocytes - pathology
- Tissue Donors - pathology
- Tumor Stem Cells - pathology
- Find related publications in this database (Keywords)
- Lymphoma
- Posttransplantation Lymphoproliferative Disorder
- Renal Transplantation
- T-Cell
- B-Cell