Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Goeritzer, M; Kuentzel, KB; Beck, S; Korbelius, M; Rainer, S; Bradić, I; Kolb, D; Mussbacher, M; Schrottmaier, WC; Assinger, A; Schlagenhauf, A; Rost, R; Gottschalk, B; Eichmann, TO; Züllig, T; Graier, WF; Vujić, N; Kratky, D.
Monoglyceride Lipase Deficiency Is Associated with Altered Thrombogenesis in Mice.
Int J Mol Sci. 2023; 24(4): 3116
Doi: 10.3390/ijms24043116
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- Leading authors Med Uni Graz
- Göritzer Madeleine
- Kratky Dagmar
- Küntzel Katharina Barbara
- Co-authors Med Uni Graz
- Bradic Ivan
- Eichmann Thomas
- Gottschalk Benjamin
- Graier Wolfgang
- Kolb Dagmar
- Korbelius Melanie
- Rainer Silvia
- Rost René
- Schlagenhauf Axel
- Vujic Nemanja
- Züllig Thomas
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- Abstract:
- Monoglyceride lipase (MGL) hydrolyzes monoacylglycerols (MG) to glycerol and one fatty acid. Among the various MG species, MGL also degrades 2-arachidonoylglycerol, the most abundant endocannabinoid and potent activator of the cannabinoid receptors 1 and 2. We investigated the consequences of MGL deficiency on platelet function using systemic (Mgl-/-) and platelet-specific Mgl-deficient (platMgl-/-) mice. Despite comparable platelet morphology, loss of MGL was associated with decreased platelet aggregation and reduced response to collagen activation. This was reflected by reduced thrombus formation in vitro, accompanied by a longer bleeding time and a higher blood volume loss. Occlusion time after FeCl3-induced injury was markedly reduced in Mgl-/- mice, which is consistent with contraction of large aggregates and fewer small aggregates in vitro. The absence of any functional changes in platelets from platMgl-/- mice is in accordance with lipid degradation products or other molecules in the circulation, rather than platelet-specific effects, being responsible for the observed alterations in Mgl-/- mice. We conclude that genetic deletion of MGL is associated with altered thrombogenesis.
- Find related publications in this database (using NLM MeSH Indexing)
- Mice - administration & dosage
- Animals - administration & dosage
- Monoglycerides - administration & dosage
- Monoacylglycerol Lipases - genetics
- Endocannabinoids - metabolism
- Lipolysis - administration & dosage
- Mice, Inbred C57BL - administration & dosage
- Mice, Knockout - administration & dosage
- Find related publications in this database (Keywords)
- platelets
- MGL
- in vitro and in vivo thrombus formation
- platelet activation
- platelet aggregation