Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Schimpl, G; Pesendorfer, P; Steinwender, G; Feierl, G; Ratschek, M; Höllwarth, ME.
Allopurinol and glutamine attenuate bacterial translocation in chronic portal hypertensive and common bile duct ligated growing rats.
GUT 1996 39: 48-53.
Doi: 10.1136/gut.39.1.48
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- Führende Autor*innen der Med Uni Graz
- Schimpl Guenther
- Co-Autor*innen der Med Uni Graz
- Feierl Gebhard
- Höllwarth Michael
- Ratschek Manfred
- Steinwender Gerhardt
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- Abstract:
- BACKGROUND: Spontaneous bacterial infections and septicaemia result in morbidity and mortality in patients with portal hypertension and obstructive jaundice. AIM: The aim of this study in rats was to investigate the incidence of bacterial translocation in portal hypertension and obstructive jaundice, and to evaluate the effects of allopurinol and glutamine. METHODS: Rats were subjected to sham laparotomy (SL), portal hypertension (PH) by calibrated stenosis of the portal vein, and common bile duct ligation (CBDL). Animals of each group were either treated with allopurinol (50 mg/kg twice a week), glutamine (1 g/kg/d), and allopurinol and glutamine. RESULTS: After four weeks, significant bacterial translocation in the untreated PH and CBDL rats occurred. Intestinal mucosal malondialdehyde concentrations (MDA), as an indicator for lipid peroxidation, and myeloperoxidase activity (MPO) released from activated neutrophils were also significantly increased (p < 0.01). Allopurinol and glutamine in PH and CBDL rats improved bacterial translocation, and decreased MDA and MPO values (p < 0.01). CONCLUSION: In PH and CBDL rats significant bacterial translocation, ileal mucosal lipid peroxidation, and neutrophil derived MPO activity occurred. Allopurinol and glutamine significantly reduced bacterial translocation, as well as ileal mucosal MDA and MPO activities.
- Find related publications in this database (using NLM MeSH Indexing)
- Allopurinol - therapeutic use
- Analysis of Variance - therapeutic use
- Animals - therapeutic use
- Bacterial Translocation - drug effects
- Cholestasis, Extrahepatic - drug therapy
- Chronic Disease - drug therapy
- Common Bile Duct - surgery
- Comparative Study - surgery
- Enzyme Inhibitors - therapeutic use
- Glutamine - therapeutic use
- Hypertension, Portal - drug therapy
- Ileum - chemistry
- Laparotomy - chemistry
- Ligation - chemistry
- Male - chemistry
- Malondialdehyde - analysis
- Peroxidase - analysis
- Random Allocation - analysis
- Rats - analysis
- Rats, Sprague-Dawley - analysis
- Find related publications in this database (Keywords)
- Bacterial Translocation
- Portal Hypertension
- Obstructive Jaundice
- Lipid Peroxidation
- Allopurinol
- Glutamine