Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Feigl, S; Fluhr, H.
Vaginal microbiome and premature birth
GYNAKOL ENDOKRINOL. 2022;
Doi: 10.1007/s10304-022-00471-5
Web of Science
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Feigl Sarah
- Fluhr Herbert
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Background The rate of preterm birth is increasing worldwide. Vaginal infections pose an important risk factor. Objective What role do infections play as the cause for preterm birth? What is the composition of the vaginal microbiome during pregnancy and what is its importance in the detection and treatment of preterm labor. Material and methods A literature search was performed in PubMed on infections and preterm birth, premature rupture of membranes and the vaginal microbiome. Results Bacterial vaginosis, depletion of Lactobacillus spp. and high microbial diversity in the vaginal microbiome are associated with an increased risk of preterm birth. Antibiotic treatment of bacterial vaginosis in symptomatic women lowers the risk of preterm birth. Screening of asymptomatic pregnant women with the aim of prevention of preterm birth is currently not recommended. The fetal microbiome and immune system begin to develop during pregnancy, whereby the nutrition and antibiotic use during pregnancy play an important role. Conclusion The vaginal microbiome influences the course of pregnancy. Clinically, it can be hard to distinguish a healthy vaginal microbiome from vaginal dysbiosis. Microbiome analyses contribute to a better understanding of pathological changes; however, due to individual differences there is no general definition of a "healthy microbiome"
- Find related publications in this database (Keywords)
- Vaginosis
- bacterial
- Vaginal dysbiosis
- Probiotics
- Lactobacillus
- Antibiotic treatment